Crosstalk of CARD9/BCL10 and STING Signalling in Nucleic Acid Immunity (A10)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452

Cytosolic nucleic acid sensing drives inflammatory responses in part by activating CARD9/BCL10-mediated NF-κB activation. Gain-of-function mutations in the nucleic acid signalling molecule STING induce the autoinflammatory disease SAVI (STING-associated vasculopathy with onset in infancy). By crossing mice that express a SAVI-associated STING variant to BCL10-deficient animals, we made the intriguing observation that the loss of BCL10 signalling substantially aggravates the SAVI pathology and significantly reduces the life span of SAVI mice. Here, we want to dissect the molecular regulation and pathophysiological function of CARD9/BCL10 signalling during aberrant STING function.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 237: Nucleic Acid Immunity
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Jürgen Ruland