Defining and targeting subtype specific inflammatory drivers in pancreatic cancer (P06)

• Subject Area: Gastroenterology
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492

The molecular and cellular mechanisms linking the immune system with pro-tumorigenic signaling pathways in PDAC cells and their microenvironment are poorly defined. We will systematically dissect inflammatory signals derived from defined tumor subtypes and their microenvironment and investigate how these signals influence PDAC progression, therapeutic efficacy and treatment resistance. With our experiments, we aim to uncover targetable inflammatory drivers and develop novel treatment strategies for translation into the clinic in the future.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1321: Modelling and Targeting Pancreatic Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Dieter Saur; Professor Dr. Marc Schmidt-Supprian; Professor Dr. Fabian Theis