Project Details
Projekt
Linking the intestinal microbiome and immune mediated effects to primary tumor growth and therapy (16)
Subject Area
Hematology, Oncology
Gastroenterology
Gastroenterology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496
We aim to examine how systemically elevated Reg3β levels can block tumorigenesis. Considering that tumor suppression is correlated with an increased CD8+ T cell infiltration into tumors as well as changes in the intestinal microbiome we intend to evaluate whether Reg3-induced dysbiosis promotes a tumor suppressive adaptive immune response and whether Reg3 can serve as a sensitizer for immune checkpoint blockade.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1292:
Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
Applicant Institution
Johannes Gutenberg-Universität Mainz
Project Head
Professor Dr. Florian R. Greten
