Astrocyte- and dendritic cell-specific function of the deubiquitinating enzyme Cezanne (OTUD7B) in experimental cerebral malaria (A30*)

• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

A30N will assess astrocyte- and dendritic cell (DC)-specific function of the deubiquitinating enzyme (DUB) OTUD7B in the course of experimental cerebral malaria (ECM). The project aims to identify (1) the interaction partners of OTUD7B in astrocytes and DCs, (2) the type of ubiquitin modification and (3) the structural domains necessary for OTUD7B function. A30N will further aid the understanding of signal transduction and intercellular immune cell communication in a clinically relevant model of CNS infection. A30N will cooperate with other CRC854 projects having expertise in NF-B signaling (A04), DUBs (A05), CNS infection (A25, A28N), astrocyte biology (A29N) and 2-photon microscopy (B31N, Z01).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Dr. Gopala Krishna Nishanth; Xu Wang, Ph.D.