Control of T cell motility by the biophysical properties of the tumor stroma (C10*)

• Subject Area: Cell Biology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

This project will study the impact of tumor-associated fibroblasts on ECM remodeling and its influence on T cell infiltration. Breast, gastrointestinal and cutaneous squamous cell cancers will be used as working models. Physical proximity between T cells and cancer cells is required for T cell-mediated killing. Therefore, to understand the biophysical properties of the ECM and its influence on T cell migration and infiltration ability in the tumor microenvironment towards the tumor cells will be the ultimately goal to optimize T cell-based therapies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Susana Minguet, Ph.D.