Integrated Co-clinical Analysis of 3-D Tumor Organoids to Target Invasion and Metastasis in Pancreatic Cancer (C09*)

• Subject Area: Hematology, Oncology ; Cell Biology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

The applicants will exploit a unique and continuously growing collection of 3-D tumor organoids derived from patients undergoing treatment for pancreatic ductal adenocarcinoma (PDAC). The goal of the project is to identify and validate potential biomarkers and therapeutic target structures of the migratory, invasive and metastatic capacity of individual patient-derived tumors based on a combined comprehensive molecular and ex vivo co-clinical functional analysis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professorin Dr. Melanie Börries; Dr. Ralph Fritsch