Synthesis of Chondrochloren A

• Applicant: Professor Dr. Markus Kalesse
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 397324012

This project aims at the first total synthesis chondrochloren. The most prominent structural features of the chondrochlorens are a rare Z-Enamide unit and a polyoxygenated middle fragment. Both fragments are synthetically challenging and we plan to establish synthetic solutions within this project. As the pivotal transformation the Ullmann-Goldberg coupling joins the polyoxygenated fragment with the aromatic fragment and established the challenging Z-Enamide.

• DFG Programme: Research Grants