Project Details
Projekt
Enterococci in allogeneic stem cell transplantation – indicators of loss of diversity or true GvHD pathogens? (B13)
Subject Area
Parasitology and Biology of Tropical Infectious Disease Pathogens
Hematology, Oncology
Immunology
Hematology, Oncology
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634
Experiments within the first funding period showed a considerable heterogeneity of genomes as well as functional (inflammatory) activities among a series of more than 300 enterococcal strains isolated from HSCT patients, which however were rather constant within individual patients and more aggressive in enterococci isolated from acute GvHD patients. These enterococcal strains will now be transferred in germfree animal models of acute GvHD to confirm individual pathogenicity. In addition, tissue translocation of enterococci as well as their interaction with local and systemic immune reactions (cellular and humoral) will be analyzed to further characterize their assumed pathogeneic role in GvHD.
DFG Programme
CRC/Transregios
Subproject of
TRR 221:
Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
Applicant Institution
Universität Regensburg
