Centralized data management and analysis facilities

• Applicant: Professor Dr. Dirk Isbrandt
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 377782854

This project is concerned with providing research data management services to scientists in the RU by harmonizing phenotype information, providing a central reference point for research results and bulk standardized processing of exome data. Integration of diverse data sets is key to the genetics projects (P1-P3), which will be primarily supported through standardized pipelines. The functional projects P4-P8 will be supported through software solutions for research collaboration and experimental planning with respect to data flow and formats. By providing crucial data management support, this project will ensure standardized data handling and will assist in arriving at valid research findings in the other projects. Research data management was performed by scientists the day they started collecting specimens and exchanging findings with their peers. The digital age brought many new technologies for measurements but thereby enhanced the data in volume and variety which complicated scientific studies. Large and heterogeneous data sources, which are typical for today’s biomedical research in general. This RU will produce and analyze DNA and RNA sequences beyond a Petabyte in bulk, but also functional and imaging as well as clinical data which requires a dedicated management for storing, processing, archiving and exchanging data to avoid inconsistencies and biases in advance.

• DFG Programme: Research Units
• Subproject of: FOR 2715: Epileptogenesis of genetic epilepsies
• International Connection: Denmark, Luxembourg
• Partner Organisation: Fonds National de la Recherche
• Cooperation Partners: Professor Dr. Konstantin Khodosevich; Dr. Roland Krause; Patrick May, Ph.D.; Professor Dr. Alexander Skupin