VE-cadherin modifications and binding partners regulate endothelial junctions (B01)

• Subject Area: Cell Biology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

The induction of vascular permeability and the entry of leukocytes into tissue are hallmarks of inflammation. VE-cadherin is a central adhesion molecule that that controls junction integrity and whose its activity is regulated by the vascular endothelial protein tyrosine phosphatase (VE-PTP). In this proposal we want to investigate the molecular mechanisms whereby various tyrosine residues control the adhesive function of VE-cadherin in vivo. In addition, we will analyze the relevance of the interaction of VE-cadherin with VEGFR2, with plakoglobin and with vinculin (via -catenin) for the regulation of endothelial junctions in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Dietmar Vestweber