Modification and adaptor function of the B cell signaling proteins Syk and SHP-1 (P07)

• Subject Area: Cell Biology
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

Signals emitted from the B cell antigen receptor are processed by the spleen tyrosine kinase (Syk) and are controlled by the protein tyrosine phosphatase SHP-1. With a new Fab-based proximity ligation assay, we discovered that Syk opens and activates the antigen receptor via an inside-out signaling mechanism. We now want to study this novel signaling process in more detail. Furthermore we will determine the function of several novel substrates of Syk and SHP-1, namely the transcription factor Foxp1 and the arginine methyl transferase PRMT1 that is regulated by the adaptor protein BTG2.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Michael Reth