GSC 226:  Göttingen Graduate School for Neurosciences and Molecular Biosciences (GGNB)

• Subject Area: Basic Research in Biology and Medicine ; Neurosciences
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39092696

• Final Report Year: 2019

Final Report Abstract

Founded in 2007, the Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences (GGNB) became established as a permanent interdisciplinary scientific institution of the University of Göttingen in 2018, operated jointly by the faculties of Biology & Psychology, Chemistry and Physics, the University Medical Center, the German Primate Center and three local Max-Planck Institutes. Irrespective of their institutional affiliation, professors and junior group leaders have examiner rights and can supervise doctoral researchers Since its inception, the GGNB and its currently 15 doctoral programs had a major impact on the scientific development of the participating institutions, the initiation of joint collaborative research alliances, recruitment of new faculty members and the integration of research institutions across institutional boundaries, creating a sense of identity among its members (faculty and doctoral researchers). The main goal of the GGNB is to promote excellence by training and supervision of doctoral researchers in the life sciences, building upon a tradition of interdisciplinary cooperation between internationally renowned scientists and taking joint responsibility for individual guidance. The GGNB is committed to support its doctoral researchers by providing the best possible training and professional development through structured support, high quality research qualification, comprehensive career services extending to early-stage postdoctoral scientists, and the promotion of scientific networks for its current and former members. The degree of collaboration reached within the GGNB is best reflected by an impressive output of joint publications between GGNB researchers. By now, the GGNB has achieved all of its main goals, including quality assurance through panelbased admission of its doctoral researchers, a comprehensive qualification program leaving the freedom of choice in a tailor-made personalized curriculum, close supervision through thesis advisory committees (three independent faculty members, supervision agreement, regular meetings and reports), as well as structured support of career development and alumni networks. The time to completion of the doctoral thesis is, on average, 3.6 years and the dropout rate is at 4%. When the GGNB became a permanent graduate center, it joined forces with the Georg-August University School of Sciences (GAUSS), the umbrella institution for all doctoral researchers in the natural sciences and mathematics. The revised GAUSS-wide doctoral degree regulations define new common standards. Most elements of the qualification program initiated by the GGNB have been merged with measures taken by other GAUSS programs. The support of early-stage researchers is now managed by a GAUSS-wide Career Service Unit for late-stage doctoral researchers and postdoctoral scientists, also promoting alumni networks.

Link to the final report

https://doi.org/10.2314/KXP:1698964048

Publications

• (2010) A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol 12(1):47
  Kardash E, Reichman-Fried M, Maitre J, Boldajipour B, Papusheva E, Messerschmidt E, Heisenberg C, Raz E
  
• (2010) Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice. Science 328(5979):753-756
  Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa R, Cota P, Wittnam J, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A
  
• (2010) Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat Struct Mol Biol 17(2):210
  Schulz E, Dickmanns A, Urlaub H, Schmitt A, Muehlenhoff M, Stummeyer K, Schwarzer D, Gerardy- Schahn R, Ficner R
  
• (2010) Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nat Struct Mol Biol 17(2):216
  Schneider M, Hsiao H, Will C, Giet R, Urlaub H, Luehrmann R
  
• (2010) NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol 17(11):1367
  Guettler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Goerlich D
  
• (2010) Olfactory Coding with Patterns of Response Latencies. Neuron 67(5):872-884
  Junek S, Kludt E, Wolf F, Schild D
  
• (2010) SNARE Protein Recycling by alpha SNAP and beta SNAP Supports Synaptic Vesicle Priming. Neuron 68(3):473-487
  Burgalossi A, Jung S, Meyer G, Jockusch W, Jahn O, Taschenberger H, O′Connor V, Nishiki T, Takahashi M, Brose N, Rhee J
  
• (2011) A readily retrievable pool of synaptic vesicles. Nat Neurosci 14(7):833-9
  Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
  
• (2011) A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat Biotechnol 29(10):942
  Brakemann T, Stiel A, Weber G, Andresen M, Testa I, Grotjohann T, Leutenegger M, Plessmann U, Urlaub H, Eggeling C, Wahl M, Hell S, Jakobs S
  
• (2011) A Size Barrier Limits Protein Diffusion at the Cell Surface to Generate Lipid-Rich Myelin-Membrane Sheets. Dev Cell 21(3):445-456
  Aggarwal S, Yurlova L, Snaidero N, Reetz C, Frey S, Zimmermann J, Paehler G, Janshoff A, Friedrichs J, Mueller D, Goebel C, Simons M
  
• (2011) Choosing Goals, Not Rules: Deciding among Rule-Based Action Plans. Neuron 70(3):536-548
  Klaes C, Westendorff S, Chakrabarti S, Gail A
  
• (2011) Diffraction-unlimited all-optical imaging and writing with a photochromic GFP. Nature 478(7368):204-208
  Grotjohann T, Testa I, Leutenegger M, Bock H, Urban N, Lavoie-Cardinal F, Willig K, Eggeling C, Jakobs S, Hell S
  
• (2011) Kinetics of Conformational Sampling in Ubiquitin. Angew Chem, Int Ed 50(48):11437-11440
  Ban D, Funk M, Gulich R, Egger D, Sabo T, Walter K, Fenwick R, Giller K, Pichierri F, de Groot B, Lange O, Grubmueller H, Salvatella X, Wolf M, Loidl A, Kree R, Becker S, Lakomek N, Lee D, Lunkenheimer P, Griesinger C
  
• (2012) Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1. Nat Neurosci 15(9):1198
  Effertz T, Nadrowski B, Piepenbrock D, Albert J, Goepfert M
  
• (2012) Drosophila Auditory Organ Genes and Genetic Hearing Defects. Cell 150(5):1042-1054
  Senthilan P, Piepenbrock D, Ovezmyradov G, Nadrowski B, Bechstedt S, Pauls S, Winkler M, Moebius W, Howard J, Goepfert M
  
• (2012) Functional Neuroimaging and Transcranial Electrical Stimulation. Dev Cell 43(3):200-208
  Turi Z, Paulus W, Antal A
  
• (2012) Membrane Fusion Intermediates via Directional and Full Assembly of the SNARE Complex. Science 336(6088):1581-1584
  Hernandez J, Stein A, Behrmann E, Riedel D, Cypionka A, Farsi Z, Walla P, Raunser S, Jahn R
  
• (2012) Nanoscopy in a Living Mouse Brain. Science 335(6068):551-551
  Berning S, Willig K, Steffens H, Dibaj P, Hell S
  
• (2012) Response to Comment on "Universality in the Evolution of Orientation Columns in the Visual Cortex. Science 336( 6080):413
  Keil W, Kaschube M, Schnabel M, Kisvarday Z, Loewel S, Coppola D, White L, Wolf F
  
• (2012) The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells. Mol Cell 46(5):705-713
  Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, Koenig A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen S
  
• (2012) The Permeability of Reconstituted Nuclear Pores Provides Direct Evidence for the Selective Phase Model. Cell 150(4):738-751
  Huelsmann B, Labokha A, Goerlich D
  
• (2012) The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev 26(21):2422-2434
  Mozaffari Jovin S, Santos K, Hsiao H, Will C, Urlaub H, Wahl M, Luehrmann R
  
• (2013) Blocking Endocytosis Enhances Short-Term Synaptic Depression under Conditions of Normal Availability of Vesicles. Neuron 80(2):343-349
  Hua Y, Woehler A, Kahms M, Haucke V, Neher E, Klingauf J
  
• (2013) Combinatorial Nucleoside-Deletion-Scanning Mutagenesis of Functional DNA. Angew Chem, Int Ed 52(10):2995-2999
  Samanta B, Hoebartner C
  
• (2013) EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues. Science 339(6115):85-88
  Doerfel L, Wohlgemuth I, Kothe C, Peske F, Urlaub H, Rodnina M
  
• (2013) Energy barriers and driving forces in tRNA translocation through the ribosome. Nat Struct Mol Biol 20(12):1390-1396
  Bock L, Blau C, Schroeder G, Davydov I, Fischer N, Stark H, Rodnina M, Vaiana A, Grubmueller H
  
• (2013) Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8. Science 341(6141):80-84
  Mozaffari-Jovin S, Wandersleben T, Santos K, Will C, Luehrmann R, Wahl M
  
• (2013) Molecular Profiling of Synaptic Vesicle Docking Sites Reveals Novel Proteins but Few Differences between Glutamatergic and GABAergic Synapses. Neuron 78(2):285-297
  Boyken J, Gronborg M, Riedel D, Urlaub H, Jahn R, Chua J
  
• (2013) N-H Spin-Spin Couplings: Probing Hydrogen Bonds in Proteins. Angew Chem, Int Ed 52(12):3525-3528
  Xiang S, Narayanan R, Becker S, Zweckstetter M
  
• (2013) SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. Nat Cell Biol 15(2):179-188
  Werner A, Disanza A, Reifenberger N, Habeck G, Becker J, Calabrese M, Urlaub H, Lorenz H, Schulman B, Scita G, Melchior F
  
• (2013) Sub-angstromresolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem (9):762-767
  Luedtke S, Neumann P, Erixon K, Leeper F, Kluger R, Ficner R, Tittmann K
  
• (2013) Targeted decay of a regulatory small RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA. Genes Dev (5):552-564
  Goepel Y, Papenfort K, Reichenbach B, Vogel J, Goerke B
  
• (2014) Cell biology. Powering the cell cycle. Science 346(6213):1059-1060
  Schulz C, Rehling P
  
• (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344(6187):1023-1028
  Wilhelm B, Mandad S, Truckenbrodt S, Kroehnert K, Schaefer C, Rammner B, Koo S, Classen G, Krauss M, Haucke V, Urlaub H, Rizzoli S
  
• (2014) Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution. Science 343(6176):1264-1266
  Mueller D, Cherukuri P, Henningfeld K, Poh C, Wittler L, Grote P, Schlueter O, Schmidt J, Laborda J, Bauer S, Brownstone R, Marquardt T
  
• (2014) Ion permeation in K+ channels occurs by direct Coulomb knock-on. Science 346(6207):352-355
  Köpfer D, Song C, Gruene T, Sheldrick G, Zachariae U, de Groot B
  
• (2014) Myelin Membrane Wrapping of CNS Axons by PI(3,4,5) P3- Dependent Polarized Growth at the Inner Tongue. Cell 156(1-2):277-290
  Snaidero N, Moebius W, Czopka T, Hekking L, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons D, Nave K, Simons M
  
• (2014) Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nat Methods 11(10):1064-1070
  Kramer K, Sachsenberg T, Beckmann B, Qamar S, Boon K, Hentze M, Kohlbacher O, Urlaub H
  
• (2014) Programmed -1 frameshifting by kinetic partitioning during impeded translocation. Cell 157(7):1619-1631
  Caliskan N, Katunin V, Belardinelli R, Peske F, Rodnina M
  
• (2014) Site-Specific Labeling of RNA at Internal Ribose Hydroxyl Groups: Terbium-Assisted Deoxyribozymes at Work. J Am Chem Soc 136(22):8131-8137
  Buettner L, Javadi-Zarnaghi F, Hoebartner C
  
• (2014) The Protein Targeting Factor Get3 Functions as ATP-Independent Chaperone under Oxidative Stress Conditions. Mol Cell 56(1):116-127
  Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth D, Schwappach B, Jakob U
  
• (2014) Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis. Neuron 83(6):1389-1403
  Chapochnikov N, Takago H, Huang C, Pangrsic T, Khimich D, Neef J, Auge E, Göttfert F, Hell S, Wichmann C, Wolf F, Moser T
  
• (2014) Vesicular Glutamate Transporters Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter. Neuron 84(6):1287-1301
  Preobraschenski J, Zander J, Suzuki T, Ahnert-Hilger G, Jahn R
  
• (2015) Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells. Cell Metab 22(3):361-363
  Trevisiol A, Nave K
  
• (2015) Cell type- and brain region-resolved mouse brain proteome. Nat Neurosci 18(12):1819-1831
  Sharma K, Schmitt S, Bergner C, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch U, Philips M, Rossner M, Mann M, Simons M
  
• (2015) Crystal structure of the metazoan Nup62.Nup58.Nup54 nucleoporin complex. Science 350(6256):106-110
  Chug H, Trakhanov S, Huelsmann B, Pleiner T, Goerlich D
  
• (2015) Mic10 Oligomerizes to Bend Mitochondrial Inner Membranes at Cristae Junctions. Cell Metab 21(5):756-763
  Barbot M, Jans D, Schulz C, Denkert N, Kroppen B, Hoppert M, Jakobs S, Meinecke M
  
• (2015) Multiple Paramagnetic Effects through a Tagged Reporter Protein. Angew Chem, Int Ed 54(1):336-339
  Camacho Zarco A, Munari F, Wegstroth M, Liu W, Ubbink M, Becker S, Zweckstetter M
  
• (2015) Sampling of Glycan-Bound Conformers by the Anti-HIV Lectin Oscillatoria agardhii agglutinin in the Absence of Sugar. Angew Chem, Int Ed 54(22):6462-6465
  Carneiro M, Koharudin L, Ban D, Sabo T, Trigo-Mourino P, Mazur A, Griesinger C, Gronenborn A, Lee D
  
• (2015) Secondary-Ion Mass Spectrometry of Genetically Encoded Targets. Angew Chem, Int Ed 54(19):5784-5788
  Vreja I, Kabatas S, Saka S, Krohnert K, Hoeschen C, Opazo F, Diederichsen U, Rizzoli S
  
• (2015) Sip1 Downstream Effector ninein Controls Neocortical Axonal Growth, Ipsilateral Branching, and Microtubule Growth and Stability. Neuron 85(5):998-1012
  Srivatsa S, Parthasarathy S, Molnar Z, Tarabykin V
  
• (2015) Superresolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies. ACS Nano 9(11):11034-11041
  Vreja I, Nikic I, Göttfert F, Bates M, Kröhnert K, Outeiro T, Hell S, Lemke E, Rizzoli S
  
• 2015) MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Mol Cell 59(2):243-257
  Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine A, Moll U, Dobbelstein M
  
• (2016) Broken detailed balance at mesoscopic scales in active biological systems. Science 352(6285):604-607
  Battle C, Broedersz C, Fakhri N, Geyer V, Howard J, Schmidt C, MacKintosh F
  
• (2016) Cilia-based flow network in the brain ventricles. Science 353(6295):176-178
  Faubel R, Westendorf C, Bodenschatz E, Eichele G
  
• (2016) Crystal structure of a DNA catalyst. Nature 529(7585):231-U272
  Ponce-Salvatierra A, Wawrzyniak-Turek K, Steuerwald U, Höbartner C, Pena V
  
• (2016) Engineered non-Mendelian inheritance of entire parental genomes in C. elegans. Nat Biotechnol 34(9):982
  Besseling J, Bringmann H
  
• (2016) MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell 61(1):68-83
  Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen S, Moll U, Zhang X, Dobbelstein M
  
• (2016) Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol Cell 64(2):307-319
  Cretu C, Schmitzová J, Ponce-Salvatierra A, Dybkov O, De Laurentiis, Sharma K, Will C, Urlaub H, Lührmann R, Pena V
  
• (2016) mRNA quality control is bypassed for immediate export of stress-responsive transcripts. Nature 540(7634):593-596
  Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, Krebber H
  
• (2016) Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles. Science 351(6276):981-984
  Farsi Z, Preobraschenski J, van den Bogaart G, Riedel D, Jahn R, Woehler A
  
• (2016) The Low Barrier Hydrogen Bond in the Photoactive Yellow Protein: A Vacuum Artifact Absent in the Crystal and Solution. J Am Chem Soc 138(51):16620-16631
  Graen T, Inhester L, Clemens M, Grubmüller H, Groenhof G
  
• (2016) X-rays Reveal the Internal Structure of Keratin Bundles in Whole Cells. ACS Nano 10(3):3553-3561
  Hémonnot C, Reinhardt J, Saldanha O, Patommel J, Graceffa R, Weinhausen B, Burghammer M, Schroer C, Köster S
  
• (2017) Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation. Neuron 93(2):394-408
  Liu YL, Cui L, Schwarz MK, Dong Y, Schlüter OM
  
• (2017) Backbone assignment of perdeuterated proteins by solid-state NMR using proton detection and ultrafast magic-angle spinning. Nat Protoc 12(4):764-782
  Fricke P, Chevelkov V, Zinke M, Giller K, Becker S, Lange A
  
• (2017) Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA. Mol Cell 66(4):558-567
  Caliskan N, Wohlgemuth I, Korniy N, Pearson M, Peske F, Rodnina MV
  
• (2017) Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542(7641):318-323
  Bertram K, Agafonov D, Liu W, Dybkov O, Will C, Hartmuth K, Urlaub H, Kastner B, Stark H, Luehrmann R
  
• (2017) Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170(4):701-713
  Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Lührmann R, Stark H
  
• (2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nat Commun 8:14241
  Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Bohler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G
  
• (2017) Flexible information routing by transient synchrony. Nat Neurosci 20(7):1014
  Palmigiano A, Geisel T, Wolf F, Battaglia D
  
• (2017) Imaging of Biological Materials and Cells by X-ray Scattering and Diffraction. ACS Nano 11(9):8542-8559
  Hemonnot CYJ, Köster S
  
• (2017) INA complex liaises the F1Fo-ATP synthase membrane motor modules. Nat Commun 8:1237
  Naumenko N, Morgenstern M, Rucktaschel R, Warscheid B, Rehling P
  
• (2017) Kinetic Requirements for Spatiotemporal Chemical Imaging with Fluorescent Nanosensors. ACS Nano 11(4):4017-4027
  Meyer D, Hagemann A, Kruss S
  
• (2017) Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat Commun 8:15578
  Haselbach D, Schrader J, Lambrecht F, Henneberg F, Chari A, Stark H
  
• (2017) Model-free inference of direct network interactions from nonlinear collective dynamics. Nat Commun 8:2192
  Casadiego J, Nitzan M, Hallerberg S, Timme M
  
• (2017) One-thousand-fold enhancement of high field liquid nuclear magnetic resonance signals at room temperature. Nat Chem 9(7):676-680
  Liu GQ, Levien M, Karschin N, Parigi G, Luchinat C, Bennati M
  
• (2017) RNF40 regulates gene expression in an epigenetic context-dependent manner. Genome Biol 18:32
  Xie WH, Nagarajan S, Baumgart SJ, Kosinsky RL, Najafova Z, Kari V, Hennion M, Indenbirken D, Bonn S, Grundhoff A, Wegwitz F, Mansouri A, Johnsen SA
  
• (2017) Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature 551(7679):204-209
  Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P
  
• (2018) Adhesion of Chlamydomonas microalgae to surfaces is switchable by light. Nat Phys 14(1):45-49
  Kreis CT, Le Blay M, Linne C, Makowski MM, Bäumchen O
  
• (2018) Chromatin swelling drives neutrophil extracellular trap release. Nat Commun 9:3767
  Neubert E, Meyer D, Rocca F, Gunay G, Kwaczala-Tessmann A, Grandke J, Senger-Sander S, Geisler C, Egner A, Schön MP, Erpenbeck L, Kruss S
  
• (2018) Correlative microscopy approach for biology using X-ray holography, X-ray scanning diffraction and STED microscopy. Nat Commun 9:3641
  Bernhardt M, Nicolas JD, Osterhoff M, Mittelstädt H, Reuss M, Harke B, Wittmeier A, Sprung M, Köster S, Salditt T
  
• (2018) Electromechanical vortex filaments during cardiac fibrillation. Nature 555(7698):667
  Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuss G, Gilmour RF, Luther S
  
• (2018) IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses. Nat Commun 9:5400
  Babaev O, Cruces-Solis H, Chatain CP, Hammer M, Wenger S, Ali H, Karalis N, de Hoz L, Schlüter OM, Yanagawa Y, Ehrenreich H, Taschenberger H, Brose N, Krueger-Burg D
  
• (2018) Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane. Nat Commun 9:4028
  Schendzielorz AB, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, Chacinska A, Rehling P
  
• (2018) PNA Hybrid Sequences as Recognition Units in SNARE-Protein-Mimicking Peptides. Angew Chem, Int Ed 57(45):14932-14936
  Hubrich BE, Kumar P, Neitz H, Grunwald M, Grothe T, Walla PJ, Jahn R, Diederichsen U
  
• (2018) Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones. Nat Commun 9:290
  Neef J, Urban NT, Ohn TL, Frank T, Jean P, Hell SW, Willig KI, Moser T
  
• (2018) RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes. Nat Commun 9:5383
  Brüning L, Hackert P, Martin R, Gallesio JD, Aquino GRR, Urlaub H, Sloan KE, Bohnsack MT
  
• (2018) RNA polymerase II clustering through carboxy-terminal domain phase separation. Nat Struct Mol Biol 25(9):833-840
  Boehning M, Dugast-Darzacq C, Rankovic M, Hansen AS, Yu T, Marie-Nelly H, McSwiggen DT, Kokic G, Dailey GM, Cramer P, Darzacq X, Zweckstetter M
  
• (2018) Structure and Conformational Dynamics of the Human Spliceosomal B- act Complex. Cell 172(3):454-464
  Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Luhrmann R, Stark H
  
• (2018) Structure determination from single molecule X- ray scattering with three photons per image. Nat Commun 9:2375
  von Ardenne B, Mechelke M, Grubmüller H
  
• (2018) Surface Properties Determining Passage Rates of Proteins through Nuclear Pores. Cell 174(1):202-217
  Frey S, Rees R, Schünemann J, Ng SC, Fünfgeld K, Huyton T, Görlich D
  
• (2019) Activity Correlations between Direction-Selective Retinal Ganglion Cells Synergistically Enhance Motion Decoding from Complex Visual Scenes. Neuron 101(5):963-976.e7
  Kuhn NK, Gollisch T
  
• (2019) Boron-Containing Probes for Non-optical High-Resolution Imaging of Biological Samples. ANGEW CHEM, INT ED 58(11):3438-3443
  Kabatas S, Agui-Gonzalez P, Saal KA, Jähne S, Opazo F, Rizzoli SO, Phan NTN
  
• (2019) Near physiological spectral selectivity of cochlear optogenetics. Nat Commun 10:1962
  Dieter A, Duque-Afonso CJ, Rankovic V, Jeschke M, Moser T
  
• (2019) NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nat Commun 10:1467
  Fledrich R, Akkermann D, Schutza V, Abdelaal TA, Hermes D, Schaffner E, Soto-Bernardini MC, Götze T, Klink A, Kusch K, Krueger M, Kungl T, Frydrychowicz C, Möbius W, Brück W, Müller WC, Bechmann I, Sereda MW, Schwab MH, Nave KA, Stassart RM
  
• (2019) Promoter Distortion and Opening in the RNA Polymerase II Cleft. Mol Cell 73(1):97-106.e4
  Dienemann C, Schwalb B, Schilbach S, Cramer P
  
• (2019) Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nat Commun 10:3639
  Keiper S, Papasaikas P, Will CL, Valcarcel J, Girard C, Lührmann R
  
• (2019) Structural basis of TFIIH activation for nucleotide excision repair. Nat Commun 10:2885
  Kokic G, Chernev A, Tegunov D, Dienemann C, Urlaub H, Cramer P
  
• (2019) Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science 363(6422): eaav1483
  Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, Wang YT, Fischer A, Dean C
  
• (2019) The pause-initiation limit restricts transcription activation in human cells. Nat Commun 10:3603
  Gressel S, Schwalb B, Cramer P