GSC 214:  Jena School for Microbial Communication (JSMC)

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2007 to 2018
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39071934

• Final Report Year: 2020

Final Report Abstract

The “Jena School for Microbial Communication” (JSMC) was established in 2006 to investigate the communication of microorganisms with other microorganisms as well as with plants, animals including humans and with the abiotic environment. The integrative analysis of results in these three research and training areas contributes to a holistic view of microbial communication and microbiology in general. The education of young scientists within THE JSMC involves non-university research institutions and includes direct participation of companies with exchange of results in collaborative PhD projects. In extension of eleven thematically related Master programmes at the Friedrich Schiller University Jena (FSU), the JSMC attracts highly motivated doctoral researchers from all over the world who are then trained in a structured, interdisciplinary, research-oriented program. The communication of microorganisms relies on presentation and recognition of abiotic and biotic molecules, such as metal ions or the metabolites of bacteria, fungi and higher organisms. The production and decoding of these signalling mediators result in the regulation and development of cellular processes as a response to the environmental and inter-organismal interactions or changes of conditions. The long-term goal of the JSMC is to provide detailed insights into production, excretion, spatial distribution, detection and translation of signals to understand their interactive networks. The interdisciplinary approach established within the JSMC involves biology, chemistry, medicine, geology, opto-physics and systems biology, and is essential to establish model descriptions of homo- and heterogeneous microbial consortia in the environment or as associated with a host. In addition to a high scientific output, an extraordinary involvement and dedication of the doctoral researchers in organising meetings, public outreach, exchange with biotech companies and developing the curricula has resulted from the programme. Moreover, the JSMC has been an essential step in internationalisation with about 40 % of doctoral researchers currently being recruited from abroad, which is substantially higher than the 18% of international doctoral researchers for the whole of the FSU. The JSMC has also been instrumental in developing a doctoral researcher culture at the FSU, which is manifested in various cultural and social events and the organisation of doctoral students in the representative body DR.FSU. Finally, several collaborative research centers and a research Cluster of Excellence have emerged directly from the scholarly network that was established by the JSMC. With the termination of funding for graduate schools by the DFG under the excellence strategy that now focusses on research clusters, the JSMC has secured funding from the Carl Zeiss foundation until the end of 2024, with possibility for extension thereafter. The funding from the Zeiss foundation was awarded for the express purpose of closer aligning doctoral training in the life and optical sciences and will be achieved by uniting the strengths of the JSMC with the Abbe School of Photonics (ASP) under the umbrella of the Jena Alliance of Graduate Schools “Life in Focus”. Objectives or future development include further progressing the mentoring and training of doctoral researchers and its extension to young researchers at the early postdoctoral level. At the same time, we will continue to develop the industry cooperation in Jena with internships for doctoral researchers and postdocs who are interested in a career outside academia in direct collaboration with the Zeiss foundation. In sum, the research and training established by the JSMC will continue to provide a strong basis for the education of competitive and successful scientists in academia and industry.

Publications

• (2008) Non-uniform distribution of glucosinolates in Arabidopsis thaliana leaves has important consequences for plant defense. Proc Natl Acad Sci USA 105: 6196
  Shroff R, Vergara F, Muck A, Svatoš A, Gershenzon J
  (See online at https://doi.org/10.1073/pnas.0711730105)
• (2009) Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics. Proc Natl Acad Sci USA 106: 10092
  Schroff R, Rulíšek L, Doubský J, Svatoš A
  (See online at https://doi.org/10.1073/pnas.0900914106)
• (2009) Divergent investment strategies of Acacia myrmecophytes and the coexistence of mutualists and exploiters. Proc Natl Acad Sci USA 106: 18091
  Heil M, González-Teuber M, Clement L W, Kautz S, Verhaagh M, Bueno S
  (See online at https://doi.org/10.1073/pnas.0904304106)
• (2009) Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation. Blood 114: 2439
  Heinen S, Hartmann A, Lauer N, Wiehl U, Dahse HM, Schirmer S, Gropp K, Enghardt T, Wallich R, Halbich S, Mihlan M, Schlotzer-Schrehardt U, Zipfel PF, Skerka C
  (See online at https://doi.org/10.1182/blood-2009-02-205641)
• (2009) Hidden biosynthetic treasures brought to light. Nat Chem Biol 5: 450
  Hertweck C
  (See online at https://doi.org/10.1038/nchembio0709-450)
• (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci USA 106: 14558
  Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W, Schümann J, Martin K, Hertweck C, Brakhage AA
  (See online at https://doi.org/10.1073/pnas.0901870106)
• (2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460: 1117
  Aimanianda V, Bayry J, Bozza S, Kniemeyer O, Perruccio K, Elluru SR, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latgé JP
  (See online at https://doi.org/10.1038/nature08264)
• (2010) Genome sequence of the model mushroom Schizophyllum commune. Nature Biotechnology 28: 957
  Ohm RA, de Jong JF, Lugones LG, Aerts A, Kothe E, Stajich JE, de Vries RP, Record E, Levasseur A, Baker SE, Bartholomew KA, Coutinho PM, Erdmann S, Fowler TJ, Gathman AC, Lombard V, Henrissat B, Knabe N, Kües U, Lilly WW, Lindquist E, Lucas S, Magnuson JK, Piumi F, Raudaskoski M, Salamov A, Schmutz J, Schwarze FW, vanKuyk PA, Horton JS, Grigoriev IV, Wösten HA
  (See online at https://doi.org/10.1038/nbt.1643)
• (2010) Reductive dehalogenation of brominated ethenes by Sulfurospirillum multivorans and Desulfitobacterium hafniense PCE-S. Environ Microbiol 12: 501
  Ye LD, Schilhabel A, Bartram S, Boland W, Diekert G
  (See online at https://doi.org/10.1111/j.1462-2920.2009.02093.x)
• (2010) Regulation of extrafloral nectar secretion by jasmonates in lima bean is light dependent. Proc Natl Acad Sci USA 107: 17228
  Radhika V, Kost C, Mithöfer A, Boland W
  (See online at https://doi.org/10.1073/pnas.1009007107)
• (2011) Bacteria induced natural product formation in the fungus Aspergillus nidulans requires Saga / Ada mediated histone acetylation. Proc Natl Acad Sci USA 108: 14282
  Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Hertweck C, Strauss J, Brakhage AA
  (See online at https://doi.org/10.1073/pnas.1103523108)
• (2011) Beta-2 glycoprotein 1 (beta-2GPI), the major target in anti phospholipid syndrome (APS), is a special human complement regulator. Blood 118: 2774
  Gropp K, Weber N, Reuter M, Micklisch S, Kopka I, Hallstroem T, Skerka C
  (See online at https://doi.org/10.1182/blood-2011-02-339564)
• (2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50 : 9843
  Scherlach K, Nützmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C
  (See online at https://doi.org/10.1002/anie.201104488)
• (2011) Plasmonic nanofabrication by long-range excitation transfer via DNA nanowire. Nano Lett 11: 1505
  Wirth J, Garwe F, Hahnel G, Csaki A, Jahr N, Stranik O, Paa W, Fritzsche W
  (See online at https://doi.org/10.1021/nl104269x)
• (2012) Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew Chem Int Ed Engl 51: 2425
  Behnken S, Lincke T, Kloss F, Ishida K, Hertweck C
  (See online at https://doi.org/10.1002/anie.201108214)
• (2012) Far-field imaging for direct visualization of light interference in GaAs nanowires. Nano Lett 12: 5412
  Grange R, Brönstrup G, Kiometzis M, Sergeyev A, Richter J, Leiterer C, Fritzsche W, Gutsche C, Lysov A, Prost W, Tegude FJ, Pertsch T, Tünnermann A, Christiansen S
  (See online at https://doi.org/10.1021/nl302896n)
• (2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51: 13173
  Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C
  (See online at https://doi.org/10.1002/anie.201206658)
• (2012) Liver dysfunction and phosphatidylinositol- 3- kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLOS Medicine 9: e1001338
  Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carré JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M
  (See online at https://doi.org/10.1371/journal.pmed.1001338)
• he Heliconius Genome Consortium (2012) Butterfly genome reveals promiscuous exchange of mimicry adaptations among species. Nature 487: 94
  Dasmahapatra K K, ... Jiggins C D
  (See online at https://doi.org/10.1038/nature11041)
• (2013) Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew Chem Int Ed Engl 52: 1590
  Forseth RR, Amaike S, Schwenk D, Affeldt KJ, Hoffmeister D, Schroeder FC, Keller NP
  (See online at https://doi.org/10.1002/anie.201207456)
• (2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13: 29
  Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G
  (See online at https://doi.org/10.1016/j.chom.2012.11.013)
• (2013) Metabolomics enables the structure elucidation of a Diatom sex pheromone. Angewandte Chemie 52: 854
  Gillard J, Frenkel J, Devos V, Sabbe K, Paul C, Rempt M, Inzé D, Pohnert G, Vuylsteke M, Vyverman W
  (See online at https://doi.org/10.1002/anie.201208175)
• (2013) Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. Proc Natl Acad Sci USA 110: 4194
  Frick S, Nagel R, Schmidt A, Bodemann R, Rahfeld P, Pauls G, Brandt W, Gershenzon J, Boland W, Burse A
  (See online at https://doi.org/10.1073/pnas.1221489110)
• (2013) Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl 52: 5285
  Busch B, Ueberschaar N, Behnken S, Sugimoto Y, Werneburg M, Traitcheva N, He J, Hertweck C
  (See online at https://doi.org/10.1002/anie.201301322)
• (2013) Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 369: 111
  Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, Ferrara F, Fazi P, Cicconi L, Di Bona E, Specchia G, Sica S, Divona M, Levis A, Fiedler W, Cerqui E, Breccia M, Fioritoni G, Salih HR, Cazzola M, Melillo L, Carella AM, Brandts CH, Morra E, von Lilienfeld- Toal M, Hertenstein B, Wattad M, Lübbert M, Hänel M, Schmitz N, Link H, Kropp MG, Rambaldi A, La Nasa G, Luppi M, Ciceri F, Finizio O, Venditti A, Fabbiano F, Döhner K, Sauer M, Ganser A, Amadori S, Mandelli F, Döhner H, Ehninger G, Schlenk RF, Platzbecker U
  (See online at https://doi.org/10.1056/NEJMoa1300874)
• (2013) Small molecules intercept Notch signalling and the early secretory pathway. Nat Chem Biol 9: 731
  Krämer A, Mentrup T, Kleizen B, Rivera-Milla E, Reichenbach D, Enzensperger C, Nohl R, Täuscher E, Görls H, Ploubidou A, Englert C, Werz O, Arndt HD, Kaether C
  (See online at https://doi.org/10.1038/NCHEMBIO.1356)
• (2014) Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed Engl 53: 13409
  Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C
  (See online at https://doi.org/10.1002/anie.201407624)
• (2014) Cell type-specific delivery of short interfering RNAs by dyefunctionalised theranostic nanoparticles. Nature Communications 5: 5565
  Press AT, Traeger A, Pietsch C, Mosig A, Wagner M, Jbeily N, Koch N, Gottschaldt M, Ermolayev V, Beziere N, Popp J, Kessels M, Qualmann B, Clemens MG, Ntziachristos V, Schubert US, Bauer M
  (See online at https://doi.org/10.1038/ncomms6565)
• (2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124: 144
  Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF
  (See online at https://doi.org/10.1172/JCI71866)
• (2014) Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles. Angew Chem Int Ed Engl 53: 11645
  Heine D, Bretschneider T, Sundaram S, Hertweck C
  (See online at https://doi.org/10.1002/anie.201407282)
• (2014) Plasmonicallyenhanced electron escape from gold nanoparticles and their polarization-dependent excitation transfer along DNA nanowires. Nano Letters 14: 3809
  Wirth J, Garwe F Mayer R, Csaki A, Stranik O, Fritzsche W
  (See online at https://doi.org/10.1021/nl5009184)
• (2014) Polarization-resolved near-field mapping of plasmonic aperture emission by a dual-SNOM system. Nano Lett 14: 5010
  Klein AE, Janunts N, Steinert M, Tünnermann A, Pertsch T
  (See online at https://doi.org/10.1021/nl501431y)
• (2014) Resolving a misconception about structured illumination. Nature Photonics 8: 342
  Wicker K, Heintzmann R
  (See online at https://doi.org/10.1038/nphoton.2014.88)
• (2014) Structural basis for organohalide respiration. Science 346: 455
  Bommer M, Kunze C, Fesseler J, Schubert T, Diekert G, Dobbek H
  (See online at https://doi.org/10.1126/science.1258118)
• (2014). Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes. Nucl Acids Res 42: 10927
  Jetha K, Theißen G, Melzer R
  (See online at https://doi.org/10.1093/nar/gku755)
• (2015) Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods 12: 445
  Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Göthert JR, Nimmerjahn F, Gunzer M
  (See online at https://doi.org/10.1038/NMETH.3322)
• (2015) Defining the transcriptomic landscape of Candida glabrata by RNA- Seq. Nucleic Acids Res 43: 1392
  Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O
  (See online at https://doi.org/10.1093/nar/gku1357)
• (2015) Detection of vancomycin in neterococci within 3 ½ hours. Sci Rep 5: 8217
  Schröder UC, Beleites C, Assmann C, Glaser U, Hübner U, Pfister W, Fritzsche W, Popp J, Neugebauer U
  (See online at https://doi.org/10.1038/srep08217)
• (2015) Metabolic cross-feeding via intercellular nanotubes among bacteria. Nat Comm 6: 6238
  Pande S, Shitut S, Freund L, Westermann M, Bertels F, Colesie C, Bischofs I B, Kost C
  (See online at https://doi.org/10.1038/ncomms7238)
• (2015) Native rootassociated bacteria rescue a plant from a sudden-wilt disease that emerged during continuous cropping. PNAS 112: E5013
  Santhanam R, Luu VT, Weinhold A, Goldberg J, Oh Y, Baldwin IT
  (See online at https://doi.org/10.1073/pnas.1505765112)
• (2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching. Nat Chem Biol 11: 949
  Sundaram S, Heine D, Hertweck C
  (See online at https://doi.org/10.1038/NCHEMBIO.1932)
• (2015) Pyridine-type alkaloid composition affects bacterial community composition of floral nectar. Scientific Reports 5: 11536
  Aizenberg-Gershtein Y, Izhaki I, Santhanam R, Kumar P, Baldwin I T, Halpern M
  (See online at https://doi.org/10.1038/srep11536)
• (2015) Tracking heavy water (D2O) incorporation for identifying and sorting active mircobial cells. PNAS 112: E194
  Berry D, Mader E, Lee TK, Woebken D, Wang Y, Zhu D, Palatinszky M, Schintlmeister A, Schmid MC, Hanson BT, Shterzer N, Mizrahi I, Rauch I, Decker T, Bocklitz T, Popp J, Gibson CM, Fowler PW, Huang WE, Wagner M
  (See online at https://doi.org/10.1073/pnas.1420406112)
• (2016) A blue-light photoreceptor mediates the feedback regulation of photosynthesis. Nature 537: 563
  Petroutsos D, Tokutsu R, Maruyama S, Flori S, Greiner A, Magneschi L, Cusant L, Kottke T, Mittag M, Hegemann P, Finazzi G, Minagawa J
  (See online at https://doi.org/10.1038/nature19358)
• (2016) A sex-inducing pheromone triggers cell cycle arrest and mate attraction in the diatom Seminavis robusta. Sci Rep 6: 19252
  Moeys S, Frenkel J, Lembke C, Gillard JT, Devos V, Van den Berge K, Bouillon B, Huysman MJ, De Decker S, Scharf J, Bones A, Brembu T, Winge P, Sabbe K, Vuylsteke M, Clement L, De Veylder L, Pohnert G, Vyverman W
  (See online at https://doi.org/10.1038/srep19252)
• (2016) Altered carbon turnover processes and microbiomes in soils under long-term extrely high CO2 exposure. Nat Microbiol 1: 15025
  Beulig F, Urich T, Nowak M, Trumbore SE, Gleixner G, Gilfillan GD, Fjelland KE, Küsel K
  (See online at https://doi.org/10.1038/NMICROBIOL.2015.25)
• (2016) Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed Engl 55: 8944
  Klapper M, Götze S, Barnett R, Willing K, Stallforth P
  (See online at https://doi.org/10.1002/anie.201603312)
• (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532: 64
  Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR
  (See online at https://doi.org/10.1038/nature17625)
• (2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6: 27807
  Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT
  (See online at https://doi.org/10.1038/srep27807)
• (2016) Dual species transcriptional profling during system candidiasis reveals organ-speficic host-pathogen interactions. Sci Rep 6: 39423
  Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID
  (See online at https://doi.org/10.1038/srep36055)
• (2016) Immune modulation enables a specialist insect to benefit from antibacterial withanolides in its host plant. Nat comm 7:12530
  Barthel A, Vogel H, Pauchet Y, Pauls G, Kunert G, Groot AT, Boland W, Heckel DG, Heidel-Fischer HM
  (See online at https://doi.org/10.1038/ncomms12530)
• (2016) Plant-like biosynthesis of isoquiline alkaloids in Aspergillus fumigatus. Nat Chem Biol 12: 419
  Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC
  (See online at https://doi.org/10.1038/NCHEMBIO.2061)
• (2016) Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. PNAS 113: E1306
  Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H
  (See online at https://doi.org/10.1073/pnas.1518189113)
• (2016) Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 167: 1067
  Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A
  (See online at https://doi.org/10.1016/j.cell.2016.09.050)
• (2016) Selective silicatedirected motility in diatoms. Nat Comm 7: 10540
  Bondoc KG, Heuschele J, Gillard J, Vyverman W, Pohnert G
  (See online at https://doi.org/10.1038/ncomms10540)
• (2016) Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells. Sci Rep 6: 24155
  Galler K, Requardt RP, Glaser U, Markwart R, Bocklitz T, Bauer M, Popp J, Neugebauer U
  (See online at https://doi.org/10.1038/srep24155)
• (2016) Standardizing the resolution claims for coherent microscopy. Nature Photonics 9: 68
  Horstmeyer R, Heintzmann R, Popescu G, Waller L, Yang C
  (See online at https://doi.org/10.1038/nphoton.2015.279)
• (2016) Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat Chem Biol 12: 6
  Kries H, Caputi L, Stevenson CEM, Kamileen MO, Sherden NH, GeuFlores F, O’Connor SE
  (See online at https://doi.org/10.1038/nchembio.1955)
• (2016) The crystal structure of Peroxiredoxin Asp f3 profides mechanistic insight into oxidative stress resistance and virulence of Aspergillus fumigatus. Sci Rep 6: 33396
  Hillmann F, Bagramyan K, Straßburger M, Heinekamp T, Hong TB, Bzymek KP, Williams JC, Brakhage AA, Kalkum M
  (See online at https://doi.org/10.1038/srep33396)
• (2016) Tuning of Spectral and Angular Distribution of Scattering from Single Gold Nanoparticles by Subwavelength Interference Layers. Nano Letters 14: 570
  Wirth J, Garwe F, Bergmann J, Paa W, Csaki A, Stranik O, Fritzsche W
  (See online at https://doi.org/10.1021/nl4037438)
• (2017) A new solution concept for the ultimatum game leading to the Golden Ratio. Sci Rep 7: 5642
  Schuster S
  (See online at https://doi.org/10.1038/s41598-017-05122-5)
• (2017) Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells. Nat Comm 8: 1756
  Aiyar P, Schaeme D, García-Altares M, Carrasco Flores D, Dathe H, Hertweck C, Sasso S, Mittag M
  (See online at https://doi.org/10.1038/s41467-017-01547-8)
• (2017) Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism. Nat Comm 8: 15172
  Flórez L V, Scherlach K, Gaube P, Ross C, Sitte E, Hermes C, Rodrigues A, Hertweck C, Kaltenpoth M
  (See online at https://doi.org/10.1038/ncomms15172)
• (2017) De novo evolved interference competition promotes the spread of biofilm defectors. Nat comm 8: 15127
  Martin M, Dragos A, Hölscher T, Maroti G, Balint B, Westermann M, Kovacs AT
  (See online at https://doi.org/10.1038/ncomms15127)
• (2017) Discovery of an extended austinoid biosynthetic pathway in Aspergillus calidoustus. ACS Chem Biol 12: 1227
  Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA
  (See online at https://doi.org/10.1021/acschembio.7b00003)
• (2017) Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase. Angew Chem Int Ed 56: 5937
  Brandt P, Garcia-Altares M, Nett M, Hertweck C, Hoffmeister D
  (See online at https://doi.org/10.1002/anie.201700767)
• (2017) Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. PNAS 114: E347
  Lackner G, Peters EE, Helfrich EJ, Piel J
  (See online at https://doi.org/10.1073/pnas.1616234114)
• (2017) Insights into the red algae and eukaryotic evolution from the genome of Porphyra umbilicalis (Bangiophyceae, Rhodophyta). Proc Natl Acad Sci USA 114: E6361
  Brawley SH, Blouin NA, Ficko-Blean E, Wheeler GL, Lohr M, Goodson HV, Jenkins JW, Blaby-Haas CE, Helliwell KE, Chan CX, Marriage TN, Bhattacharya D, Klein AS, Badis Y, Brodie J, Cao Y, Collén J, Dittami SM, Gachon CMM, Green BR, Karpowicz SJ, Kim JW, Kudahl UJ, Lin S, Michel G, Mittag M, Olson BJSC, Pangilinan JL, Peng Y, Qiu H, Shu S, Singer JT, Smith AG, Sprecher BN, Wagner V, Wang W, Wang ZY, Yan J, Yarish C, Zäuner- Riek S, Zhuang Y, Zou Y, Lindquist EA, Grimwood J, Barry KW, Rokhsar DS, Schmutz J, Stiller JW, Grossman AR, Prochnik SE
  (See online at https://doi.org/10.1073/pnas.1703088114)
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