GSC 185:  Leipzig School of Natural Sciences - Building with Molecules and Nano-objects (BuildMoNa)

• Subject Area: Condensed Matter Physics
• Term: from 2007 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39011260

• Final Report Year: 2015

Final Report Abstract

The challenge and promise of nanoscience is that traditionally diverse disciplines are transforming themselves to merge into a new type of integrated multi-science, as demanded by their common subject of interest. This rapid development urgently calls for a new generation of researchers, trained not only to survive in this post-disciplinary environment but to grasp and harness its innovative potential creatively. The educational programme that we have developed during the first funding period of the Graduate School BuildMoNa is a highly successful contribution towards meeting these challenges. It is a novel type of materials and biomaterials science study programme that emphasises the role of nanostructuring in the design of smart and adaptive multifunctional materials. Thanks to our strongly interdisciplinary research and training we have multiplied our abilities to understand, synthesise, control and manipulate our nanoscopic building blocks, thus providing a toolbox to create novel materials with unexpected properties out of them. Our bottom-up strategy has brought the universal principles of self-assembly, coarse-graining and the emergence of complex functionalities increasingly into the focus of our attention. The challenge then was to comprehend and predict the emerging multiscale properties and processes starting from the nanoscopic building blocks. Emergent phenomena influence rational design in all three focus areas of BuildMoNa: smart molecules, multifunctional scaffolds, and complex nanostructures. In the last three years, we have put even stronger emphasis on potential targets for applications by aligning the course and module programme according to three applied themes that emphasise central aims and methodological strengths of the graduate school. These themes are (i) smart and active assemblies, (ii) chemical biology and biophysics of cancer, and (iii) quantum coherent structures. Based on our experiences in the first funding period, the training modules have been restructured and optimised accordingly, and are now organised in a transparent three-stage course programme. The main training modules are accompanied by introductory modules that bridge interdisciplinary gaps. Three advanced modules and mini-symposia link directly with on-going research and technological applications. The Graduate School BuildMoNa bundles the most prolific research activities in the natural science division of Universität Leipzig together with close ties to other prominent scientific institutions in Leipzig. With its highly interdisciplinary, technologically oriented international research and qualification programme, its strong embedding into regional and global innovative industries, and its commitment to scientific excellence, the Graduate School BuildMoNa is firmly established as a cornerstone of the scientific and educational development plan of Universität Leipzig.

Link to the final report

http://dx.doi.org/10.2314/GBV:882998951

Publications

• A Practical, Self-Catalytic, Atomic Layer Deposition of Silicon Dioxide. Angew. Chem. Int. Ed. 47 (2008) 6177; Angew. Chem. 120 (2008) 6272
  J. Bachmann, R. Zierold, Y.T. Chong, R. Hauert, Ch. Sturm, R. Schmidt-Grund, B. Rheinländer, M. Grundmann, U. Gösele, K. Nielsch
  
• Functional Immobilization of Signaling Proteins Enables Control of Stem Cell Fate. Nat. Methods 5 (2008) 645
  K. Alberti, R.E. Davey, K. Onishi, S. George, K. Salchert, F.P. Seib, M. Bornhäuser, T. Pompe, A. Nagy, C. Werner, P.W. Zandstra
  
• Neue chemische Verbindungen, deren Herstellung und deren Verwendung. DE 102007026701 A1 (2008), WO 2008/145733 (2008)
  E. Hey-Hawkins, M. Scholz
  
• Factors Relevant for the Regioselective Cyclopolymerization of 1,6-Heptadiynes, N,N-Dipropargylamines, N,N- Dipropargylammonium Salts, and Dipropargyl Ethers by Ru-IV-Alkylidene-Based Metathesis Initiators. J. Am. Chem. Soc. 131 (2009) 387
  P.S. Kumar, K. Wurst, M.R. Buchmeiser
  
• Trapping of a Thiolate → Dibromine Charge-Transfer Adduct by a Macrocyclic Dinickel Complex and its Conversion to an Arenesulfenyl Bromide Derivative. Angew. Chem. Int. Ed. 48 (2009) 1954; Angew. Chem. 121 (2009) 1988
  G. Steinfeld, V. Lozan, H.-J. Krüger, B. Kersting
  
• 45] M. Grundmann, T. Böntgen, M. Lorenz: The Occurrence of Rotation Domains in Heteroepitaxy. Phys. Rev. Lett. 105 (2010) 146102
  M. Grundmann, T. Böntgen, M. Lorenz
  
• A Novel Organotypic Tauopathy Model on a New Microcavity Chip for Bioelectronic Label-Free and Real Time Monitoring. Biosens. Bioelec. 26 (2010) 162
  D. Krinke, H.-G. Jahnke, T.G.A. Mack, A. Hirche, F. Striggow, A.A. Robitzki
  
• Are Biomechanical Changes Necessary for Tumour Progression? Nat. Phys. 6 (2010) 730
  A. Fritsch, M. Höckel, T. Kiessling, K.D. Nnetu, F. Wetzel, M. Zink, J.A. Käs
  
• Breast Cancer Diagnosis by Neuropeptide Y Analogues – First Clinical Approach. Angew. Chem. Int. Ed. 49 (2010) 1155
  I.U. Khan, D. Zwanziger, I. Böhme, M. Javed, H. Naseer, S.W. Hyder, A.G. Beck-Sickinger
  
• Film Lift-Off from MgO: Freestanding Single Crystalline Fe-Pd Films Suitable for Magnetic Shape Memory Actuation – and Beyond. Adv. Mat. 22 (2010) 4969
  T. Edler, S.G. Mayr
  
• Hot Brownian Motion. Phys. Rev. Lett. 105 (2010) 090604
  D. Rings, R. Schachoff, M. Selmke, F. Cichos, K. Kroy
  
• Ion Chemistry Mediated by Water Networks. Science 327 (2010) 280
  K. Siefermann, B. Abel
  
• Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates. Angew. Chem. Int. Ed. 49 (2010) 9530
  M. Bachmann, K. Goede, A.G. Beck-Sickinger, M. Grundmann, A. Irbäck, W. Janke
  
• Recent Progress on ZnO-Based Metal-Semiconductor Field-Effect Transistors and their Application in Transparent Integrated Circuits. Adv. Mater. 22 (2010) 5332
  H. Frenzel, A. Lajn, H. von Wenckstern, M. Lorenz, F. Schein, Zh. Zhang, M. Grundmann
  
• Surface Plasmons on Embedded Gold Nanodot-Matrices Made by Diffraction Mask Projection Laser Ablation. Nano Lett. 10 (2010) 47
  M. Mäder, T. Höche, J.W. Gerlach, S. Perlt, J. Dorfmüller, R. Vogelgesang, K. Kern, B. Rauschenbach
  
• Systematic Microcanonical Analyses of Polymer Adsorption Transitions. PhysChemChemPhys 12 (2010) 11548
  M. Möddel, W. Janke, M. Bachmann
  
• Theoretical Investigation of Solvent Effects and Complex Systems: Toward the Calculations of Bioinorganic Systems from Ab Initio Molecular Dynamics Simulations and Static Quantum Chemistry. Adv. Inorg. Chem. 62 (2010) 111
  M. Bruessel, S. Zahn, E. Hey-Hawkins, B. Kirchner
  
• Transparente gleichrichtende Metall-Metalloxid-Halbleiterkontaktstruktur und Verfahren zu seiner Herstellung und Verwendung. DE 102009030045 B3 (2010), WO 2010/149616 (2010)
  H. Frenzel, A. Lajn, H. von Wenckstern, M. Grundmann
  
• Tube Width Fluctuations in F-Actin Solutions. Phys. Rev. Lett. 105 (2010) 037801
  J. Glaser, D. Chakraborty, K. Kroy, I. Lauter, M. Degawa, N. Kirchgeßner, B. Hoffmann, R. Merkel, M. Giesen
  
• A Microporous Copper Metal-organic Framework with High H 2 and CO 2 Adsorption Capacity at Ambient Pressure. Angew. Chem. 50 (2011) 10344
  D. Lässig, J. Lincke, J. Moellmer, C. Reichenbach, A. Moeller, R. Gläser, G. Kalies, K.A. Cychosz, M. Thommes, R. Staudt, H. Krautscheid
  
• Ballistic Transport at Room Temperature In Micrometer-Size Graphite Flakes. Phys. Rev. B 83 (2011) 125402
  S. Dusari, J. Barzola-Quiquia, P. Esquinazi
  
• Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies. Chemical Reviews 111 (2011) 7035
  M. Scholz, E. Hey-Hawkins
  
• Carbaboranesubstituted 1,2-diphosphetanes. Angew. Chem. 50 (2011) 4701
  A. Kreienbrink, M.B. Sárosi, E.G. Rys, P. Lönnecke, E. Hey-Hawkins
  
• Dynamic Force Spectroscopy on the Binding of Monoclonal Antibodies and Tau Peptides. Soft Matter 7 (2011) 4370
  C. Wagner, D. Singer, O. Ueberschär, T. Stangner, C. Gutsche, R. Hoffmann, F. Kremer
  
• Guest Diffusion in Interpenetrating Networks of Micro- and Mesopores. J. Amer. Chem. Soc. 133 (2011) 2437
  F. Furtado, P. Galvosas, M. Gonçalvez, F.-D. Kopinke, S. Naumov, F. Rodríguez-Reinoso, U. Roland, R. Valiullin, J. Kärger
  
• Incorporation of ortho-Carbaboranyl-Nε-modified L-Lysine into Neuropeptide Y Receptor Y 1 - and Y 2 - Selective Analogues. J. Med. Chem. 54 (2011) 2368
  V.M. Ahrens, R. Frank, S. Stadlbauer, A.G. Beck-Sickinger, E. Hey-Hawkins
  
• NMR Signal Averaging in 62 T Pulsed Fields. J. Magn. Reson. 210 (2011) 1
  B. Meier, S. Greiser, J. Haase, T. Herrmannsdörfer, F. Wolff-Fabris, J. Wosnitza
  
• Signatures of Non-Abelian Statistics in Non-Linear Coulomb Blockaded Transport. Phys. Rev. Lett. 106 (2011) 136801
  R. Ilan, B. Rosenow, A. Stern
  
• Solid-State NMR of Aβ Protofibrils Implies a β-Sheet Remodelling upon Maturation into Terminal Amyloid Fibrils. Angew. Chemie Int. Ed. 50 (2011) 2837
  H.A. Scheidt, I. Morgado, S. Rothemund, D. Huster, M. Fähndrich
  
• Tensor Decomposition in Post-Hartree- Fock Methods. I. Two-Electron Integrals and MP2. J. Chem. Phys. 134, 054118 (2011)
  U. Benedikt, A.A. Auer, M. Espig, W. Hackbusch
  
• Tungsten Oxide as a Gate Dielectric for Highly Transparent and Temperature-stable Zinc-oxide-based Thin-film Transistors. Advanced Materials 23 (2011) 5383
  M. Lorenz, H. von Wenckstern, M. Grundmann
  
• Untapped Potential: Exploiting Fungi in Bioremediation of Hazardous Chemicals. Nat. Rev. Microbiol. 9 (2011) 177
  H. Harms, D. Schlosser, L.Y. Wick
  
• A Novel, Niased-like SDF-1 Derivative Acts Synergistically with StarPEG-Based Heparin Hydrogels and Improves eEPC Migration In Vitro. J. Control Release 162 (2012) 68
  L. Baumann, S. Prokoph, C. Gabriel, U. Freudenberg, C. Werner, A.G. Beck-Sickinger
  
• Assessment of Hydrogen Storage by Physisorption in Porous Materials. Energy Environ. Sci. 5 (2012) 8294
  M. Bastos-Neto, C. Patzschke, M. Lange, J. Möllmer, A. Möller, S. Fichtner, C. Schrage, D. Lässig, J. Lincke, R. Staudt, H. Krautscheid, R. Gläser
  (See online at https://doi.org/10.1039/c2ee22037g)
• Can Doping Graphite Trigger Room Temperature Superconductivity? Evidence for Granular High-temperature Superconductivity in Water-treated Graphite Powder. Advanced Materials 24 (2012) 5826
  T. Scheike, W. Böhlmann, P. Esqunazi, J. Barzola-Quiquia, A. Ballestar, A. Setzer
  (See online at https://doi.org/10.1002/adma.201202219)
• Eigenmodes in the Long-Time Behavior of a Coupled Spin System Measured with Nuclear Magnetic Resonance. Phys. Rev. Lett. 108 (2012) 177602
  B. Meier, J. Kohlrautz, J. Haase
  (See online at https://doi.org/10.1103/PhysRevLett.108.177602)
• Freestanding Single Crystalline Fe-Pd Ferromagnetic Shape Memory Membranes – Role of Mechanical and Magnetic Constraints across the Martensite Transition. Adv. Funct. Mater. 22 (2012) 2529
  Y. Ma, A. Setzer, J.W. Gerlach, F. Frost, P. Esquinazi, S.G. Mayr
  (See online at https://doi.org/10.1002/adfm.201103021)
• Inhibition of Human Neutrophil Elastase by alpha1-antitrypsin Functionalized Colloidal Microcarriers. ACS Nano 6 (2012) 6325
  U. Reibetanz, M. Schönberg, S. Rathmann, V. Strehlow, M. Göse, J. Leßig
  (See online at https://doi.org/10.1021/nn301791w)
• Ion-Irradiation-Assisted Phase Selection in Single Crystalline Fe7Pd3 Ferromagnetic Shape Memory Alloy Thin Films: From fcc to bcc along the Nishiyama-Wassermann Path. Phys. Rev. Lett. 109 (2012) 195704
  A. Arabi-Hashemi, S.G. Mayr
  (See online at https://doi.org/10.1103/PhysRevLett.109.195704)
• Photothermal Microscopy: Detection of a Nanolens. ACS Nano 6 (2012) 2741
  M. Selmke, M. Braun, F. Cichos
  
• Stabilization of Ferromagnetic Order in La0.7Sr0.3MnO3-SrRuO3 Superlattices. Nano Letters 12 (2012) 4276
  M. Ziese, F. Bern, E. Pippel, D. Hesse, I. Vrejoiu
  (See online at https://doi.org/10.1021/nl301963a)
• Coupling of Micromagnetic and Structural Properties across the Martensite and Curie Temperatures in Miniaturized Ni-Mn- Ga Ferromagnetic Shape Memory Alloys. Adv. Funct. Mater. 23 (2013) 4694
  A.M. Jakob, M. Hennes, M. Müller, D. Spemann, S.G. Mayr
  (See online at https://doi.org/10.1002/adfm.201300165)
• Determining the Specificity of Monoclonal Antibody HPT-101 to Tau- Peptides with Optical Tweezers. ACS Nano 7 (2013) 11388
  T. Stangner, C. Wagner, D. Singer, S. Angioletti-Uberti, C. Gutsche, J. Dzubiella, R. Hoffmann, F. Kremer
  (See online at https://doi.org/10.1021/nn405303u)
• Emergent Complexity of the Cytoskeleton: From Single Filaments to Tissue. Advances in Physics 62 (2013) 1
  F. Huber, J. Schnauß, S. Rönicke, P. Rauch, K. Müller, C. Fütterer, J.A. Käs
  (See online at https://doi.org/10.1080/00018732.2013.771509)
• Glassy Dynamics in Condensed Isolated Polymer Chains. Science 341 (2013) 1371
  M. Tress, E.U. Mapesa, W. Kossack, W.K. Kipnusu, M. Reiche, F. Kremer
  (See online at https://doi.org/10.1126/science.1238950)
• Interaction of Ferromagnetic Shape Memory Alloys and RGD Peptides for Mechanical Coupling to Cells: From Ab Initio Calculations to Cell Studies. Adv. Funct. Mater. 23 (2013) 1383
  M. Zink, F. Szillat, U. Allenstein, S.G. Mayr
  (See online at https://doi.org/10.1002/adfm.201201789)
• Keratins Significantly Contribute to Cell Stiffness and Impact Invasive Behavior. Proceedings of the National Academy of Sciences of the United States of America 110 (2013) 18507
  K. Seltmann, A.W. Fritsch, J.A. Käs, T.M. Magin
  
• Optically Controlled Thermophoretic Trapping of Single Nano-objects. ACS Nano 7 (2013) 11200
  M. Braun, F. Cichos
  (See online at https://doi.org/10.1021/nn404980k)
• Photoactivatable Chemokines – Controlling Protein Activity by Light. Angew. Chem. 125 (2013) 9729
  L. Baumann, A.G. Beck-Sickinger
  (See online at https://doi.org/10.1002/anie.201302242)
• Rapid Internal Contraction Boosts DNA Friction. Nat. Commun. 4 (2013) 1780
  O. Otto, S. Sturm, N. Laohakunakorn, U.F. Keyser, K. Kroy
  (See online at https://doi.org/10.1038/ncomms2790)
• Single Pulse Laser-Induced Phase Transitions of PLD-Deposited Ge2Sb2Te5 Films. Adv. Funct. Mater. 23 (2013) 3621
  H. Lu, E. Thelander, J.W. Gerlach, U. Decker, B. Zhu, B. Rauschenbach
  (See online at https://doi.org/10.1002/adfm.201202665)
• Superfluid Stiffness of a Driven Dissipative Condensate with Disorder. Phys. Rev. Lett. 111 (2013) 230403
  A. Janot, T. Hyart, P.R. Eastham, B. Rosenow
  (See online at https://doi.org/10.1103/PhysRevLett.111.230403)
• Adsorption and Pattern Recognition of Polymers at Complex Surfaces with Attractive Stripelike Motifs. Phys. Rev. Lett. 112 (2014) 148303
  M. Möddel, W. Janke, M. Bachmann
  (See online at https://doi.org/10.1103/PhysRevLett.112.148303)
• Adsorption of I 2 by Macrocyclic Polyazadithiophenolato Complexes Mediated by Charge-Transfer Interactions. Angew. Chem. Int. Ed. Engl. 53 (2014) 994
  M. Golecki, N. Beyer, G. Steinfeld, V. Lozan, S. Voitekhovich, M. Sehabi, J. Möllmer, H.-J. Krüger, B. Kersting
  (See online at https://doi.org/10.1002/anie.201405199)
• Asymptotic Scaling Behavior of Self-Avoiding Walks on Critical Percolation Clusters. Phys. Rev. Lett. 113 (2014) 255701
  N. Fricke, W. Janke
  (See online at https://doi.org/10.1103/PhysRevLett.113.255701)
• Metal Nanoparticle Based All-Optical Photothermal Light Modulator. ACS Nano 8 (2014) 1893
  A. Heber, M. Selmke, F. Cichos
  (See online at https://doi.org/10.1021/nn406389f)
• Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias. Angew. Chem. Int. Ed. Engl. 53 (2014) 10067
  V. Mäde, S. Babilon, N. Jolly, L. Wanka, K. Bellmann-Sickert, L.E. Diaz Gimenez, K. Mörl, H.M. Cox, V.V. Gurevich, A.G. Beck-Sickinger
  (See online at https://doi.org/10.1002/anie.201403750)
• Persistence-Length Renormalization of Polymers in a Crowded Environment of Hard Disks. Phys. Rev. Lett. 113 (2014) 238302
  S. Schöbl, S. Sturm, W. Janke, K. Kroy
  (See online at https://doi.org/10.1103/PhysRevLett.113.238302)
• Theory of Rapid Force Spectroscopy. Nat. Commun. 5 (2014) 4463
  J.T. Bullerjahn, S. Sturm, K. Kroy
  (See online at https://doi.org/10.1038/ncomms5463)