Investigation of cellular response to nanoparticle uptake by dual TEM and superresolution fluorescence imaging (C04)

• Subject Area: Physical Chemistry of Molecules, Liquids and Interfaces, Biophysical Chemistry
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

C04 investigates the internalisation of nanoparticles into cells and tissue and their association to intracellular compartments and their interactions with membranes. For this purpose, a combination of electron microscopy and high-resolution fluorescence microscopy techniques are utilised. Co-localisation of inflammatory markers, enzymes and receptors in the cellular context in response of particle uptake and drug release is used to obtain a deeper inside into the mode of action of nanoparticle formulations in the biological context.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Rainer Heintzmann; Dr. Stephanie Höppener