Targeting the mutanome of liver cancer by viral oncoly-sis and tumor-directed immunotherapies (C06+)

• Subject Area: Gastroenterology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314905040

Project C06 (Kühnel; Targeting the mutanome of liver cancer by viral oncolysis and tumor-directed immunotherapies) will analyze epitope spreading in response to the already implemented oncolytic virotherapy and PD-1 inhibition in models with defined CD4- and CD8-neoepitope spectrum. Also neoepitope-specific T-cell response pattern after virolytic therapy and the effect of immunostimulatory transgenes in epitope spreading will be analyzed in this context in order to develop optimized strategies combining virotherapy and checkpoint inhibition.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 209: Liver Cancer - New mechanistic and therapeutic concepts in a solid tumor model
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Florian Kühnel