Metabolic reprogramming and control of autophagy in HCC progression (B02+)

• Subject Area: Gastroenterology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314905040

Recent research of project B02 (Nordheim/Proikas-Cezanne; Metabolic reprogramming and control of autophagy in HCC progression) has shown that SRF driven hyperproliferation is linked to drastic metabolic changes regarding energy metabolism (aerobic glycolysis), amino acid metabolism (glutaminolysis, serine synthesis), and mTORC1-controled cellular catabolism by autophagy. The project now aims to identify the network responsible for reprogramming of energy metabolism and characterize the tumor-related functions of glutaminolysis, one-carbon metabolism, and autophagy in the HCC mouse model displaying constitutive SRF activity.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 209: Liver Cancer - New mechanistic and therapeutic concepts in a solid tumor model
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Alfred Nordheim; Professorin Dr. Tassula Proikas-Cezanne