Role of atypical IκB protein IκBζ in HCC formation (A06)

• Subject Area: Pathology
• Term: from 2017 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314905040

Project A06 (Schulze-Osthoff/Hailfinger; Role of atypical IκB protein IκBζ in HCC formation) has shown that a new class of atypical nuclear IκB proteins not only adds complexity to TNF-induced signaling but influences liver carcinogenesis via modulating the expression of a selected set of target genes including those encoding key regulatory cytokines, such as IL-6, IL-10, and CCL2. IκBζ deficiency renders mice resistant to HCC development and therefore the project aims at identifying the mechanism behind the oncogenic function of atypical IκB proteins.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 209: Liver Cancer - New mechanistic and therapeutic concepts in a solid tumor model
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Stephan Hailfinger; Professor Dr. Klaus Schulze-Osthoff