Project Details
Projekt
Macromolecular prodrug nanoparticles for antimicrobial therapy (B02)
Subject Area
Preparatory and Physical Chemistry of Polymers
Term
since 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987
B02 develops strategies to target intracellular compartments that are used by pathogenic microorganisms to escape from the immune system and are difficult to be reached by antibiotics. B02 engineers polymer nanoparticles (NPs) with targeting surfaces that allow efficient uptake by macrophages. The NPs contain antimycotics that are specifically released in phagolysosomes (PLs). A compound that enhances fusion of PLs containing pathogens with PLs containing antimycotic NPs will be developed for improving therapies.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1278:
Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
Applicant Institution
Friedrich-Schiller-Universität Jena
