Multifunctional nanoparticles based on polysaccharides for targeted drug delivery with two-step release behavior (A02)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

Polysaccharide-based nanoparticles are suitable drug carriers, which can be widely modified in terms of structures and properties. Since protein acetylation significantly affects regulation of the immune system, deacetylase inhibitors (HDACi) could be useful for the treatment of inflammation and septic shock. We develop biocompatible and functional polysaccharide-based drug-loaded nanoparticles, which will be further modified to achieve tissue-specificity suitable for clinical translation in inflammatory diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professorin Sina Maren Coldewey, Ph.D., since 7/2021; Professor Dr. Thomas Heinze; Professor Dr. Thorsten Heinzel