The plasticity-dependent spatiotemporal organization of AMPARs and scaffolding proteins (C01)

• Subject Area: Experimental and Theoretical Network Neuroscience
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Long-term changes of the synaptic strength play a fundamental role in shaping the behaviorally relevant dynamics of neuronal networks. In the first funding period, we developed a theoretical model of AMPA receptor trafficking in the postsynaptic site, considering a fixed network of scaffolding proteins. In the second funding period, we plan to extend our analysis to the plasticity-dependent, spatiotemporal dynamics of AMPA receptors interacting with diffusible scaffolding proteins, in a dynamic postsynaptic density.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Christian Tetzlaff