Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease (B09)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

A quantitative analysis of the protein composition of the synapto-axonal compartment would help to better understand the molecular basis of Parkinson’s Disease (PD), but such quantitative proteomics data of the diseased synapse are lacking so far. Although several animal models for neurodegeneration exist, it is clear that they recapitulate only part of the pathology. In this project we aim to understand the PD synapse beyond alpha-synuclein or synuclein-related elements, by revealing novel PD target proteins. We will focus especially on elements linked to the destabilization of the synapto-axonal cytoskeleton and of synapses.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Paul Lingor