Quantitative molecular physiology of calyceal synapses (B05)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Biophysics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Calyceal synapses transmit information at high rates, with sub-millisecond temporal precision. During the first funding period, we studied the roles of piccolo, bassoon and RIM-binding protein 2. Our studies also revealed a high heterogeneity of synaptic transmission and short-term plasticity. We propose that synaptic modulation through transmitters such as dopamine (DA), serotonin (5-HT), or noradrenalin (NE) contributes to the control of synaptic function, and is therefore responsible for this heterogeneity. We will test this by a combination of electrophysiology, optogenetics and imaging approaches.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Tobias Moser