The organization of the synaptic cytoskeleton (A07)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Cytoskeletal rearrangements and dynamics orchestrate several processes at the pre- and postsynaptic level. By benefitting from the recent developments of MINFLUX, a nanoscopy technique we invented, which is the first super-resolved optical method with true molecular-size resolution, we will elucidate the exact nanoscale organization of the synaptic actin cytoskeleton. We will shed light on the dynamics and molecular status of actin as a function of synaptic activity and strength by systematically analyzing the abundance and localization of proteins that regulate actin stability and dynamics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Dr. Elisa D' Este; Professor Stefan W. Hell