The role of adiponectin in the regulation of hypothalamic circadian rhythms

• Applicant: Professor Dr. Henrik Oster
• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386891684

Endogenous circadian clocks regulate physiology and behaviour along the 24-h day cycle. The circadian system and energy metabolism are tightly coupled. Central and peripheral circadian clocks coordinate key metabolic processes and the 24-h rhythms of food intake and energy expenditure. On the other hand, metabolic state can reset circadian rhythms in the periphery and the central nervous system - and in this way adapt physiological functions. The mechanisms of this metabolism-clock feedback will be studied in this project. We will use different transgenic mouse models to analyse the effect of adipose tissue-derived signals on circadian physiological and behavioural rhythms and clocks in energy metabolism-regulatory centres of the hypothalamus.

• DFG Programme: Research Grants