Tailor-made multifunctional polymers and nanoparticles with optimised compatibility between biodegradable core and encapsulated drug (A01)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

Developing new degradable hydrophobic materials such as polyesterketals and polyesteramides, the project aims at designing these polymers to maximise the encapsulation efficiency for a given drug in a combined experimental and computational approach. Atomistic simulations joined with machine learning approaches along with mesoscale simulations of real nanocarrier models will be used for computationally efficient predictions of drug loading capacity, nanoparticle formation, encapsulation and drug release.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Ulrich S. Schubert; Professor Dr. Marek Sierka