Pathophysiology and advanced approaches for subtyping in primary aldosteronism (B15)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

Identify metabolomic/steroidomic signatures by in situ MALD-MSI and Q-TOF mass spectrometry in adrenal and plasma samples for stratification of patients according to disease subtype and therapeutic outcome.(II) Elucidate transcriptome signatures in APAs and in different subgroups of APMs by untargeted spatial transcriptomics to gain insight into disease pathophysiology.(III) Establish impacts of genomic and pharmacological manipulations, related to the pathophysiology and treatment of primary aldosteronism, on steroid pathway dynamics.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Dr. Graeme Eisenhofer, Ph.D.; Professor Dr. Jacques W.M. Lenders, Ph.D., until 6/2021; Dr. Tracy Ann Williams, Ph.D.