Genetic and environmental contributors to vascular function in primary aldosteronism (B13)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Pneumology, Thoracic Surgery
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Establish and optimise (radio)synthesis of additional and improved fluorinated and iodinated derivatives of known CYP17 inhibitors.(II) Evaluate novel CYP17- and CYP11B2 inhibitors in vitro.(III) Explore the most promising radiolabelled CYP17- and CYP11B2-inhibitors in available humanised animal models.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Dr. Carmina Teresa Fuß; Professorin Dr. Stefanie Hahner; Professor Dr. Martin Reincke, until 6/2021; Dr. Andreas Schirbel, since 7/2021