The molecular pathology of PPGLs and genetically-driven molecular-targeted therapies: Towards precision medicine (B11)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Generate and characterise in vitro models of aggressive PPGLs by p27 and Runx1 modulation. (II) Identify novel drugs effective against PPGLs by drug screening.(III) Conduct proof-of-principle targeting of Hif2α in vivo.(IV) Investigate the importance of somatic mutation analysis and targeted drug testing in human PPGLs for personalised therapy decisions in terms of precision medicine.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Dr. Svenja Nölting, since 7/2021; Dr. Natalia S. Pellegata