Immunometabolic regulation of adrenal glucocorticoid production and peripheral glucocorticoid signalling (A07)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Determine the role of IL-4 and polyamines in the regulation of adrenal function. (II) Establish if IL-4 and polyamines act as regulators of peripheral glucocorticoid action in macrophages.(III) Identify the physiological function of IL-4 and polyamines in the skeleton and evaluate their role as a potential therapy for glucocorticoid-induced and inflammation-associated bone loss.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Dr. Vasileia Ismini Alexaki; Professorin Dr. Suzanne Eaton, until 6/2021 (†); Dr. Holger Henneicke, Ph.D., since 7/2021