In vitro and in vivo models of novel therapeutic approaches in congenital adrenal hyperplasia (A04)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Pediatric and Adolescent Medicine
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Develop improved antagonistic peptides suppressing the MC2R pathway.(II) Model and optimise pharmacological chaperones for rescuing CYP21A2 enzyme activity.(III) Characterise and utilise the CAH mouse model for in vivo tests of peptides and chaperones.(III) Establish a national combined paediatric and adult CAH database.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professorin Angela Hübner, Ph.D.; Privatdozentin Dr. Katrin Köhler, since 7/2021; Professorin Dr. Nicole Reisch