GRK 1038:  Catalysts and Catalytic Reactions for Organic Synthesis

• Subject Area: Molecular Chemistry
• Term: from 2005 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374870

• Final Report Year: 2015

Final Report Abstract

Chemistry in general and Organic Synthesis in particular is an enabling science, which is in many cases the basis for innovation and development in the chemical and pharmaceutical industry and beyond. The development of an environmentally benign, energy saving, sustainable and cost efficient new quality of organic synthesis is more acute than ever. Catalysis in organic synthesis can be an ideal solution to these problems. Hence, the development of ever more efficient and selective catalysts and catalytic reactions for important synthetic transformations in organic synthesis is at the forefront of molecular sciences, and has been the central research topic of this international research training group. Under the roof of the international research training group “Catalysts and Catalytic Reactions for Organic Synthesis” (IRTG 1038) six research groups from the Faculty of Chemistry and Pharmacy of the University of Freiburg and five research groups from the Department of Chemistry at the University of Basel have combined their research and teaching activities in this innovative field of research. During two funding periods this IRTG has made significant contributions to the field with a total of nearly 800 original publications (437 FR/348 Bs) from the participating key researchers involved during the two funding periods. A total of 127 PhD students (81 FR/ 46 Bs) finished their scientific education. The excellent scientific training environment of this IRTG helped these PhD students to find rapidly excellent positions in both industry and academia.

Publications

• Catalytic Desymmetrizing Intramolecular Heck Reaction: Evidence of an Unusual Hydroxy- Directed Migratory Insertion. Angew. Chem. 2005, 117, 152-155; Angew. Chem. Int. Ed. 2005, 44, 149-152
  M. Oestreich, F. Sempere-Culler, A.B. Machotta
  
• Eine neue Synthese von Z-Pulvinonen : erste Arbeiten zu einer Totalsynthese von Kodaistatin und zur Ermittlung von dessen 3D-Struktur. Freiburg
  Kaczybura, Natasza
  
• Kinetic Resolution of Chiral Secondary Alcohols by Dehydrogenative Coupling with Recyclable Silicon-Stereogenic Silanes. Angew. Chem. 2005, 117, 7793−7797; Angew. Chem. Int. Ed. 2005, 44, 7620−7624
  S. Rendler, G. Auer, M. Oestreich
  
• OMCOS 13 (Conference report). Nachr. Chem. 2005, 53, 1069
  A.B. Machotta, M. Oestreich
  
• Practical Synthesis of Allylic Silanes from Allylic Esters and Carbamates by Stereoselective Copper-Catalyzed Allylic Substitution Reactions. Adv. Synth. Catal. 2005, 347, 637−640
  M. Oestreich, G. Auer
  
• An Enantioselective Access to an Anthracycline AB Synthon by a Desymmetrizing Heck Cyclization. Synlett 2006, 2965-2968
  M. Oestreich, F. Sempere-Culler, A.B. Machotta
  
• Copper-Free and Copper-Promoted Conjugate Addition Reactions of Bis(triorganosilyl) Zincates. Synthesis 2006, 2113−2116
  G. Auer, B. Weiner, M. Oestreich
  
• Organic Chemistry Online...and for Free? (Website review). Angew. Chem. 2006, 118, 7272; Angew. Chem. Int. Ed. 2006, 45, 7114
  A.B. Machotta, M. Oestreich
  
• Preparation of a Privileged Silicon-Stereogenic Silane: Classical versus Kinetic Resolution. Adv. Synth. Catal. 2006, 348, 1171−1182
  S. Rendler, G. Auer, M. Keller, M. Oestreich
  
• Reduktive Metallierung von Silylchloriden: Darstellung von siliciumstereogenen Silylanionen und Ausgangspunkt für übergangsmetallkatalysie Silyltransferreaktionen. Freiburg
  Auer, Gertrud
  
• Rhodium-Catalyzed Enantioselective Conjugate Silyl Transfer: 1,4-Addition of Silyl Boronic Esters to cyclic Enones and Lactones. Angew. Chem. 2006, 118, 5803−5805; Angew. Chem. Int. Ed, 2006, 45, 5675−5677
  C. Walter, G. Auer, M. Oestreich
  
• Silylzincation of Carbon−Carbon Multiple Bonds Revisited. Chem. Commun. 2006, 311−313
  G. Auer, M.Oestreich
  
• Beiträge zu palladium(0)- und palladium(II)-katalysierten Heck-artigen C–C-Bindungsknüpfungen. Münster
  Machotta, Axel
  
• Directed Branched-Regioselective Hydroformylation of 2-Substituted Allylic o-DPPB Esters. Eur. J. Org. Chem. 2007, 2497-2503
  B. Breit, C. Grünanger, O. Abillard
  
• Ortho-Diphenylphosphanylbenzoyl-dirigierte Hydroformylierung als Schlüsselschritt einer iterativen Polypropionatsynthese. Freiburg
  Gebert, Antje
  
• Oxygen Donor-Mediated Equilibration of Diastereomeric Alkene–Palladium(II) Intermediates in Enantioselective Desymmetrizing Heck Cyclizations. J. Am. Chem. Soc. 2007, 129, 13455-13463
  A.B. Machotta, B. F. Straub, M. Oestreich
  
• Self-Assembled Bidentate Ligands for Ruthenium-Catalyzed Hydration of Nitriles. Organometallics 2007, 26, 2461-2464
  T. Šmejkal, B. Breit
  
• Self-Assembly of Bidentate Ligands for Combinatorial Homogeneous Catalysis: Methanol- Stable Platforms Analogous to the Adenine Thymine Base Pair. Angew. Chem. 2007, 119, 3097-3099; Angew. Chem. Int. Ed. 2007, 46, 3037-3039
  C. Waloch, J. Wieland, M. Keller, B. Breit
  
• Synthese von (R)-5,6-Dimethoxytryptophan und Arbeiten zur Totalsynthese der Indolalkaloide Geissochizin, Quaternin und Strictamin. Freiburg
  Kirchhoffer, Franz
  
• Tandem Claisen Condensations / Transesterifications Between Arylacetate Enolates and Arylmethylene-Substituted 2,2-Dimethyl-1,3-dioxolan-4-ones: An Improved Synthesis of Z-Configured Pulvinones. Synthesis 2007, 118-130
  N. Kaczybura, R. Brückner
  
• A Catalytic Asymmetric Fujiwara-Moritani Cyclization. Synlett 2008, 2271-2274
  J.A. Schiffner, A.B. Machotta, M. Oestreich
  
• A Convenient Allylic Functionalization of Bis(prop-2-enyl)methanol by Direct Trimetalation. Synthesis 2008, 3692-3696
  A. Bigot, B. Breit
  
• A Supramolecular Catalyst for Regioselective Hydroformylation of Unsaturated Carboxylic Acids. Angew. Chem. 2008, 120, 317-321; Angew. Chem. Int. Ed. 2008, 47, 311- 315
  T. Šmejkal, B. Breit
  
• A Supramolecular Catalyst for the Decarboxylative Hydroformylation of a,b-Unsaturated Carboxylic Acids. Angew. Chem. 2008, 120, 4010-4013; Angew. Chem. Int. Ed. 2008, 47, 3946-3949
  T. Šmejkal, B. Breit
  
• Allylation of N-Heterocycles with Allylic Alcohols Employing Self-Assembling Palladium Phosphane Catalysts. Org. Lett. 2008, 10, 1207-1210
  I. Usui, S. Schmidt, M. Keller, B. Breit
  
• Asymmetric Synthesis – The Essentials (Second, Completely Revised Edition). Edited by Mathias Christmann and Stefan Bräse. Wiley-VCH, Weinheim 2008 (Book review). Synthesis 2008, 1163
  A.B. Machotta, M. Oestreich
  
• Branched-Regioselective Hydroformylation with Catalytic Amounts of a Reversibly Bound Directing Group. Angew. Chem. 2008, 120, 7456-7459; Angew. Chem. Int. Ed. 2008, 47, 7346-7349
  C. U. Grünanger, B. Breit
  
• Diastereoselective synthesis of α-tocopherol. Basel
  Buss, Axel
  
• Enantioselective Synthesis of 2,6-Dideoxy Carbarsugars based on a Desymmetrizing Hydroformylation/Carbonyl Ene Cyclization Process. Chem. Commun. 2008, 6498-6500
  B. Breit, A. Bigot
  
• Mimikry von Polyketid Synthasen mit Organokatalysatoren: Rationales Design und Kombinatorisches Screening. Basel
  Lubkoll, Jana
  
• Molecular recognition in homogeneous transition metal catalysis : a biomimetic strategy for high selectivity. Freiburg
  Smejkal, Tomas
  
• One pot desymmetrizing hydroformylation carbonyl ene cyclization application to the synthesis of carbohydrate mimetics. Freiburg
  Bigot, Aurélien
  
• One-Pot Desymmetrizing Hydroformylation/Carbonyl Ene Cyclization Process: Straightforward Access to Highyl Functionalized Cyclohexanols. Org. Lett. 2008, 10, 5321-5324
  A. Bigot, D. Breuninger, B. Breit
  
• Practical Synthesis of (E)-α,β-Unsaturated Carboxylic Acids Using a One-Pot Hydroformylation/Decarboxylative Knoevenagel Reaction Sequence. Adv. Synth. Cat. 2008, 350, 989-994
  S. T. Kemme, T. Šmejkal, B. Breit
  
• Stereokomplementäre Herstellung 1,omega-distannylierter-Polyenbausteine und deren Anwendung in der jeweils ersten stereoselektiven Totalsynthese der Naturstoffe Cicutoxin und Pyrrhoxanthin. Freiburg
  Burghart, Jochen
  
• Total Synthesis of Naturally Configured Pyrrhoxanthin, a Carotenoid Butenolide from Plankton. Angew. Chem. 2008, 120, 7777-7782; Angew. Chem. Int. Ed. 2008, 47, 7664-7668
  J. Burghart, R. Brückner
  
• Totalsynthese von natürlich konfiguriertem Pyrrhoxanthin, einem Carotinoid-Butenolid aus Plankton. Total Synthesis of Naturally Configured Pyrrhoxanthin, a Carotenoid Butenolide from Plankton. Angew. Chem. 2008, 120, 7777-7782; Angew. Chem. Int. Ed. 2008, 47, 7664-7668
  J. Burghart, R. Brückner
  
• A new assay format for NF-kb based on a triple helix and a fluorescence resonance energy transfer. Org. Biomol. Chem. 2009, 7, 3934-3939; Title page
  D. Altevogt, A. Hrenn, C. Kern, L. Clima, W. Bannwarth, I. Merfort
  
• All Carbon Quaternary Centers via Ruthenium Catalyzed Hydroxymethylation of 2-Substituted Butadiene Mediated by Formaldehyde: Beyond Hydroformylation. J. Am. Chem. Soc. 2009, 131, 10366-10367
  T. Smejkal, H. Han, B. Breit, M. Krische
  
• Asymmetric synthesis of 2,2-disubstituted chromanols. Basel
  Chapelat, Julien
  
• Chromatography-free enzymatic kinetic resolution of secondary alcohols. Basel
  Maywald, Matthias
  
• Cu[Al(OR^F)4] Starting Materials and their Application in the Preparation of [Cu(Sn)]+ (n = 12, 8) Complexes. Chem. Eur. J. 2009, 15, 6663-6677
  Gustavo Santiso-Quinones, Alexander Higelin, Julia Schäfer, Robin Brückner, Carsten Knapp, Ingo Krossing
  
• Dual Palladium- and Proline-Catalyzed Allylic Alkylation of Enolizable Ketones and Aldehydes with Allylic Alcohols. Org. Lett. 2009, 11, 1453-1456
  I. Usui, S. Schmidt, B. Breit
  
• Entwicklung eines iterativen Syntheseweges für Polyketidstrukturen sowie Untersuchungen zur Synthese und Biosynthese von Gabaculin. Freiburg
  Rieder, Oliver
  
• Feasibility study for a new assay for NF-kappaB and DNA-supported catalysis. Freiburg
  Altevogt, Dominik
  
• High-Yielding Large-Scale Syntheses of Enantiomerically Pure NOBIN and a NOBIN-Based Enantiomerically Pure NHC Precursor. Synlett 2009, 109-111
  D. Sälinger, R. Brückner
  
• Intramolecular Mizoroki-Heck Reactions – Formation of Carbocycles. In The Mizoroki-Heck Reaction (Ed.: M. Oestreich), Wiley, Chichester, 2009, Chapter 5
  A.B. Machotta, M. Oestreich
  
• Iridium-katalysierte Hydrierung unfunktionalisierter Olefine. Basel
  Schrems, Marcus
  
• Iterative Synthesis of (Oligo)deoxypropionates via Zinc-Catalyzed Enantiospecific sp −sp Cross-Coupling. Org. Lett. 2009, 11, 4668-4670
  G. J. Brand, C. Studte, B. Breit
  
• Konformationsdesign und stereoselektive Synthese von Trichostatin A-Analoga als Inhibitoren von Histondesacetylasen : Synthese von Nicotinmidadenindinucleotid-Derivaten. Freiburg
  Brand, Gabriel
  
• P-Chiral phosphorus ligands: Synthesis and application in asymmetric hydrogenation. Basel
  Gschwend, Björn
  
• Peptides as catalysts for asymmetric 1,4-addition reactions of aldehydes to nitroolefins. Basel
  Wiesner, Markus
  
• Selectivity Enhancement for the Jacobsen-Katsuki Epoxidation in Fluorinated Solvents. Helv. Chim. Acta 2009, 91, 623-628
  Nizam Havare, Dietmar A. Plattner
  
• Supramolecular Catalyst for Aldehyde Hydrogenation and Tandem Hydroformylation-Hydrogenation. Angew. Chem. 2009, 121, 8166-8170; Angew. Chem. Int. Ed. 2009, 48, 8022-8026
  L. Diab, T. Smejkal, B. Breit
  
• Synthesen prochiraler Alkohole mit enantiotopen Bromalkenyl- oder Bromarylsubstituenten : Desymmetrisierung von Bis(bromaryl)alkoholen durch ersten asymetrischen Halogen/Metall-Austausch. Freiburg
  Sälinger, Daniel
  
• A combinatorial approach to the identification of self-assembled ligands for rhodium-catalyzed asymmetric hydrogenation. Nature Chemistry 2010, 2, 832-837
  J. Wieland, B. Breit
  
• Chiral pyridyl phosphinite catalysts and the development of structure selectivity relationships in the asymmetric hydrogenation of trisubstituted alkenes. Basel
  Woodmansee, David
  
• Combinatorial organocatalyst development and screening of conjugate additions. Basel
  Fleischer, Ivana
  
• Combined Transition-Metal- and Organocatalysis: An Atom Economic C3 Homologation of Alkenes to Carbonyl and Carboxylic Compounds. Chem. Eur. J. 2010, 16, 3423-3433
  S. T. Kemme, T. Smejkal, B. Breit
  
• Conversion of Conjugated Enones into Enantiomerically Pure β-Hydroxyketones or 1,3-Diols. Samarium(II)-Bromide Reductions of Protected α,β-Dihydroxyketones. Eur. J. Org. Chem. 2010, 4785-4801
  A. Zörb, R. Brückner
  
• Dual transition metal- and organo-catalyst catalyzed C-C bond formation. Freiburg
  Usui, Ippei
  
• Economic Large-Scale Synthesis of o- and m-Diphenylphosphinobenzoic Acids. Synthesis 2010, 1924-1928
  S. T. Kemme, Y. Schmidt, C. U. Grünanger, A. C. Laungani, C. Herber, B. Breit
  
• Enantioselective Total Synthesis of the Unnatural and the Natural Stereoisomers of Vittatalactone. J. Org. Chem. 2010, 75, 4424-4433
  Y. Schmidt, K. Lehr, U. Breuninger, G. Brand, T. Reiss, B. Breit
  
• Entwicklung einer kovalent aber reversibel gebundenen Katalysator-dirigierenden Gruppe für regio- und diastereoselektive Hydroformylierungen. Freiburg
  Grünanger, Christian
  
• Exceptionally Active Catalysts for the Formation of Carbamates from Alcohols and Isocyanates: Molybdenum(VI) Dichloride Dioxide and its DMF Complex. Synlett 2010, 2429-2434
  C. Stock, R. Brückner
  
• Multifunktionelle, fluoreszente PerfluorPEG-Linker : Synthese, Charakterisierung und Applikation in Einzelenzymspektroskopie, in Fluor-Fluor-Interaktionsquantifizierung und in weiteren Anwendungen. Freiburg
  Rapp, Hartmut
  
• Remote Control of Regio- and Diastereoselectivity in the Hydroformylation of Bishomoallylic Alcohols with Catalytic Amounts of a Reversibly Bound Directing Group. Angew. Chem. 2010, 122, 979-982; Angew. Chem. Int. Ed. 2010, 49, 967-970
  C. U. Grünanger, B. Breit
  
• Samarium(II)-halogenid-vermittelte Alpha-Defunktionalisierung geschützter Alpha,Beta-Dihydroxycarbonylverbindungen und deren Anwendung in Synthese von Statinseitenketten : 1,3-Diolsynthesen. Freiburg
  Zörb, Andreas
  
• Samarium(II)-halogenid-vermittelte Alpha-Defunktionalisierung geschützter Alpha,Beta-Dihydroxycarbonylverbindungen und deren Anwendung in Synthese von Statinseitenketten: 1,3-Diolsynthesen. Freiburg
  Zörb, Andreas
  
• Supramolekulare Phosphanliganden auf Basis der Adenin/Thymin- und Cytosin/Guanin- DNA-Basenpaarung: Selbstassoziierende Liganden für die homogene Katalyse. Freiburg
  Wieland, Jörg
  
• The Reaction of White Phosphorus with NO+/NO2+[Al(OR^F)4]-: The [P4NO]+ Cluster Formed by an Unexpected Nitrosonium Insertion. Angew. Chem., Int. Ed. Engl. 2010, 49, 8139-8143
  Tobias Köchner, Sebastian Riedel, Anna J. Lehner, Harald Scherer, Ines Raabe, Tobias A. Engesser, Franziska W. Scholz, Urs Gellrich, Philipp Eiden, Roberto A. Paz Schmidt, Dietmar A. Plattner, Ingo Krossing
  
• The Reaction of White Phosphorus with NO+/NO2+[Al(ORF)4]−: The [P4NO]+ Cluster Formed by an Unexpected Nitrosonium Insertion. Angew. Chem. 2010, 122, 8316–8320; Angew. Chem. Int. Ed. 2010, 49, 8138-8143
  Tobias Köchner, Sebastian Riedel, Anna J. Lehner, Harald Scherer, Ines Raabe, Tobias A. Engesser, Franziska W. Scholz, Urs Gellrich, Philipp Eiden, Roberto A. Paz-Schmidt, Dietmar A. Plattner, Ingo Krossing
  
• Transition-State Stabilization by a Secondary Substrate-Ligand Interaction: A New Design Principle For Highly Efficient Transition-Metal Catalysis. Chem. Eur. J. 2010, 16, 2470-2478
  T. Smejkal, D. Gribkov, J. Geier, M. Keller, B. Breit
  
• A Serendipitous Synthesis of (+)-Gregatin B. Second Structure Revision of the Aspertetronins, Gregatins, and Graminin A. Structure Revision of the Penicilliols. Org. Lett. 2011, 13, 2730-2733
  H. Burghart-Stoll, R. Brückner
  
• Asymmetric Dihydroxylations of 1-Substituted (E)- and (Z)-3-Methylpent-2-en-4-ynes: Full Compliance with the Sharpless Mnemonic Re-established and Embellished. Org. Lett. 2011, 13, 1020-1023
  H. Burghart-Stoll, O Böhnke, R. Brückner
  
• Asymmetric Dihydroxylations of Enynes with a Trisubstituted C=C Bond. An Unprecedented Route to γ-Lactone Building Blocks with a Quaternary Stereocenter. Org. Lett. 2011, 13, 1016-1019
  H. Burghart-Stoll, T. Kapferer, R. Brückner
  
• Chemistry in ionic liquids and prediction of their transport properties. Freiburg
  Eiden, Philipp
  
• Chirale mono- und bidentate Phosphorliganden für die enantioselektive Metall-katalysierte Hydrierung. Basel
  Frank, Dominik
  
• Diastereoselective Hydroformylation of 2,5-Cyclohexadienyl-1-carbinols with Catalytic Amounts of a Reversibly Bound Directing Group. Org. Lett. 2011, 13, 612-615
  I. Usui, K. Nomura, B. Breit
  
• Entwicklung neuer P,N-Liganden und ihre Anwendungen in der Iridium-katalysierten Hydrierung von α,β-ungesättigten Carbonsäureestern. Basel
  Tröndlin, Lars
  
• Formation of Quaternary Carbon Centers by Highly Regioselective Hydroformylation with Catalytic Amounts of a Reversibly 39Bound Directing Group. Chem Eur. J. 2011, 17, 8555-8558
  Y. Ueki, H. Ito, I. Usui, B. Breit
  
• Iron Nanoparticles Supported on Chemically-Derived Graphene: Catalytic Hydrogenation with Magnetic Catalyst Separation. Adv. Synth. Cat. 2011, 353, 523-527
  M. Stein, J. Wieland, P. Steurer, F. Tölle, R. Mülhaupt, B. Breit
  
• On the Origin of Ligand Self-Assembling Through Complementary Hydrogen-Bonding in the Coordination Sphere of a Transition Metal Center: The 6-Diphenylphosphanylpyridin-2(1H)-one system J. Am. Chem. Soc., 133, 964 (2011)
  U. Gellrich, W. Seiche, M. Keller, B. Breit, J. Huang and M. Meuwly
  
• Sn/Li Exchange Reactions in 1,w-Distannylated Conjugated Trienes and Tetraenes: An Enabling Step for Polyene Synthesis. Eur. J. Org. Chem. 2011, 150-165
  J. Burghart, R. Brückner
  
• Stereocomplementary Syntheses of 1,ω-Distannylated E,Z-Isomeric Conjugated Trienes, Tetraenes, and Pentaenes. Chem. Eur. J. 2011, 17, 6469-6483
  J. Burghart, A. Sorg, R. Brückner
  
• Stereoselective Reduction of 2-Hydroxy Ketones towards syn- and anti-1,2-Diols. Adv. Synth. Catal. 2011, 353, 2359–2362
  Syed Masood Husain, Thomas Stillger, Pascal Dünkelmann, Melanie Lödige, Lydia Walter, Elke Breitling, Martina Pohl, Mara Bürchner, Ingo Krossing, Michael Müller, Diego Romano, Francesco Molinari
  
• Stereoselective Reduction of 2-Hydroxy Ketones towards syn- and anti-1,2-Diols. Advanced Synthesis & Catalysis 2011, 353, 2359-2362
  S. M. Husain, T. Stillger, P. Dunkelmann, M. Lodige, L. Walter, E. Breitling, M. Pohl, M. Bürchner, I. Krossing, M. Müller, D. Romano, F. Molinar
  
• Strukturrevidierende Synthese von Gregatin B : Entwicklung eines variati-onsfähigen Zugangs zu den revidierten Strukturen der Aspertetronine Gregatine. Freiburg
  Burghart-Stoll, Heike
  
• Studien zur Totalsynthese von TMC-151 : Untersuchungen zur vinylogen Mukaiyama Aldolreaktion nach Kobayashi. Freiburg
  Breuninger, Ulrich
  
• [P9]+[Al(ORF)4]-, the Salt of a Homopolyatomic Phosphorus Cation. Angew. Chem. 2012, 124, 6635–6637; Angew. Chem. Int. Ed. 2012, 51, 6529-6531
  Tobias Köchner, Tobias A. Engesser, Harald Scherer, Dietmar A. Plattner, Alberto Steffani, Ingo Krossing
  
• A Se19 Homocycle Complexed by Two Copper(I) Ions. Angew. Chem. 2012, 124, 6112–6115; Angew. Chem. Int. Ed. 2012, 51, 6009-6012
  ulia Schaefer, Alberto Steffani, Dietmar A. Plattner, Ingo Krossing
  
• Attachment of Proteins to Surfaces by Fluorous-Fluorous Interactions Restoring Their Structure and Activity. ChemPlusChem 2012, 77, 1066- 1070
  H. M. Rapp, S. Bacher, A. Ahrens, W. Rapp, B. Kammerer, G. U. Nienhaus, W. Bannwarth
  (See online at https://doi.org/10.1002/cplu.201200234)
• Biomimetic asymmetric synthesis of (R)-GTRI-02 and (3S,4R)-3,4-dihydroxy-3,4-dihydronaphthalen-1(2H)-ones. Org. Lett. 2012, 14, 3600–3603
  Syed Masood Husain, Michael A. Schätzle, Caroline Röhr, Steffen Lüdeke, Michael Müller
  (See online at https://doi.org/10.1021/ol301305p)
• Chiral proline-based ligands for iridium-catalyzed asymmetric hydrogenation. Basel
  Rageot, Denise
  
• Development and evaluation of chiral catalysts for asymmetric C-C and C-H bond forming reactions. Basel
  Ebner, Christian
  
• Development of a bidentate lewis acid catalyzed inverse electron demand diels-alder reaction of 1,2-diazines for the synthesis of substituted arenes. Basel
  Kessler, Simon
  
• Drei für Zwei, die Entwicklung dreier Schlüsselmethoden für zwei neuartige Totalsynthesen der Polyol-Polyen-Makrolide Amphotericin B und RK-397: desymmetrisierende asymmetrische Dihydroxylierungen prochiraler 1,7-disubstituierter Diallyldarbinole; MoO2Cl2(DMF)2-katalysierte Additionen von Akoholen an Isocyanate; Phenylselanol-vermittelte Desoxygenierungen in alpha-Position zu Akzeptoren. Freiburg
  Stock, Christian
  
• Enantioselektive Epoxidierung mit Metall(salen)-Komplexen - Oxidative Spaltung und Umlagerung organischer Verbindungen. Freiburg
  Havare, Nizam
  
• Enzymatic reduction of anthrahydoquinones: implications für chrysophanol, monodictyphenone and related xanthone biosyntheses. J. Am. Chem. Soc. 2012, 134, 14742–14745
  Michael A. Schätzle, Syed Masood Husain, Sascha Ferlaino, Michael Müller
  
• Fluor-Fluor-Wechselwirkungen zur nicht-kovalenten Immobilisierung : Synthese und Immobilisierung von Katalysatoren an Perfluoriertem Kieselgel und in amphiphilen Systemen, sowie deren Anwendung in Diels-Alder Reaktionen und Ringschluss-Metathesen. Freiburg
  Hensle, Eva
  
• Human Carbonic Anhydrase II: a Novel Scaffold for Artificial Metallo-enzymes. Basel
  Monnard, Fabien
  
• Hydrogen-Bond and Solvent Dynamics in Transition Metal Complexes: A Combined Simulation and NMR- Investigation J. Phys. Chem. B, 116, 14406 (2012)
  J. Huang, D. Häussinger, U. Gellrich, W. Seiche, B. Breit and M. Meuwly
  (See online at https://doi.org/10.1021/jp309412r)
• Metabolische Divergenz durch NADPH-abhängige Reduktion von Ketotautomeren phenolischer Verbindungen. Freiburg
  Schätzle, Michael
  
• Mild and High-Yielding Molybdenum(VI) Dichloride Dioxide Catalyzed Formation of Mono- and Oligocarbamates from Alcohols and Aromatic or Aliphatic Isocyanates. Adv. Synth. Catal. 2012, 354, 2309-2330
  C. Stock, R. Brückner
  
• Oxidative Cleavage and Rearrangement of Aryl Epoxides Using Iodosylbenzene: on Criegee’s Trail. Helv. Chim. Acta 2012, 95, 2036-2042
  Nizam Havare, Dietmar A. Plattner
  
• Oxidative Cleavage of α-Arylaldehydes Using Iodosylbenzene. Org. Lett. 2012, 14, 5078-5081
  Nizam Havare, Dietmar A. Plattner
  
• Synthesis and Application of Strong Bronsted Acids Generated from the Lewis Acid Al(OR^F)3 and an Alcohol. Organometallics 2012, 31, 7485-7491
  A. Kraft, J. Beck, G. Steinfeld, H. Scherer, D. Himmel and I. Krossing
  (See online at https://doi.org/10.1021/om300776a)
• Synthesis and Oxidation of Hexafluoroisopropoxyborylferrocenes. Pure and Applied Chemistry 2012, 84, 2317-2324
  Hannes Böhrer, Nils Trapp, Harald Scherer, and Ingo Krossing
  (See online at https://doi.org/10.1351/PAC-CON-12-02-14)
• Synthesis, Characterization, and Application of Two Al(OR^F)3 Lewis Superacids.Chem. Eur. J. 2012, 18, 9371-9380
  Anne Kraft, Nils Trapp, Daniel Himmel, Hannes Böhrer, Peter Schlüter, Harald Scherer, and Ingo Krossing
  (See online at https://doi.org/10.1002/chem.201200448)
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