GRK 1034:  The Impact of Inherited Polymorphismus in Oncology: From Basic Science to Clinical Application

• Subject Area: Basic Research in Biology and Medicine
• Term: from 2005 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374717

• Final Report Year: 2015

Final Report Abstract

Etwa 500.000 Menschen erkranken jährlich in Deutschland an Krebs und etwa jeder vierte Mensch stirbt schließlich an einer Krebserkrankung. Fehlendes Ansprechen auf die Krebstherapie und schwere Therapie-Nebenwirkungen sind auch heute noch ernste Probleme in der Behandlung. Das Ansprechen auf die Krebstherapie hängt oft von den Mutationen ab, die sich während der Entstehung der Krebsentstehung in den Krebszellen ansammeln. Die individuelle Belastung durch Nebenwirkungen hängt dagegen oft mit der angeborenen Variation im Erbgut, also im Genom der normalen Zellen des Menschen, zusammen. Aber wir verstehen viele dieser Zusammenhänge noch nicht genug, um dieses Wissen regelmäßig in der Behandlung zum Nutzen für die Patienten berücksichtigen zu können. Zusammen mit vielen anderen Wissenschaftlerinnen und Wissenschaftlern haben die 69 Doktorandinnen und Doktoranden des Graduiertenkollegs 1034 daher untersucht, wie die Wirkweise und Wirkstärke und die Nebenwirkungen von Krebstherapien mit der angeborenen genomischen Variation beim Menschen zusammenhängen. Die Vorgänge in den menschlichen Zellen ebenso wie die therapeutischen Maßnahmen müssen im Zusammenhang aller Organsysteme, des gesamten Menschen und der jeweiligen Fachdisziplinen betrachtet werden. Daher haben im Graduiertenkolleg Forschungsgruppen aus der Grundlagenforschung mit klinischen Disziplinen der Krebstherapie (Hämatologie, Onkologie, Chirurgie, Dermatologie) eng zusammengearbeitet. Die Doktorandinnen und Doktoranden haben die genomische Variation in der Pharmakologie (Membrantransport, Metabolismus von Medikamenten und Rezeptorwirkungen), in der Genregulation, in der DNA-Reparatur, in der Immunologie, und in der Gefäßneubildung untersucht. Und schließlich wurde hier auch an verbesserte Verfahren der bioinformatischen und epidemiologischen Analyse der erblicher Variation bei Krebserkrankungen gearbeitet. Wir haben die Frage bearbeitet, wie Krebsmedikamente überhaupt in die Krebszellen gelangen, wo sie schließlich ihre Wirkung entfalten können. Dabei konnten Doktoranden aus der Physiologie, der klinischen Pharmakologie und der Chirurgie zeigen, dass jeweils einzelne Einwärts-Transportproteine (organische Anionen- und Kationentransporter) für spezifische Medikamente in der Krebstherapie wichtig sind. Unsere Untersuchungen ergaben, dass Krebszellen sehr unterschiedlich mit diesen Transportproteinen ausgestattet sind, was in Zukunft für die individuelle Therapieauswahl eine große Bedeutung haben kann. Die Regulation zwischen Zellen und innerhalb der Zellen spielt in der Krebsentstehung und Behandlung eine zentrale Rolle. Daher bearbeiteten viele der Doktorandinnen und Doktoranden die Genregulation im Immunsystem und in bösartigen Lymphdrüsenkrebserkrankungen. Es zeigten sich spezifische Muster der Dysregulation der Signalwege in den Krebszellen, was wiederum zu individualisierten Therapien beitragen kann. In einer auf die Analyse der Immunabwehr ausgerichteten Projekt konnte gezeigt werden, dass eine Genvariante im stressinduzierbaren NK-Rezeptor-Liganden MICA mit einem erhöhten Risiko der sehr schwerwiegenden Abstoßungsreaktion (graft versus host Erkrankung) nach Knochenmarktransplantation assoziiert war. Eine ebenso wichige Rolle spielt die Reparatur von Erbsubstanz-(DNA)-Schäden in der Krebsentstehung und Therapie. Wir haben neue DNA Reparatur-Genvarianten identifiziert und eine Modulation der DNA-Reparaturfähigkeit als Risiko für die Entwicklung von Krebserkrankung als auch für das Ansprechen und die Nebenwirkungen einer medikamentösen Tumortherapie aufgezeigt. Die Ergebnisse verdeutlichen die sehr erfolgreiche interdisziplinäre Zusammenarbeit aller Mitglieder des Graduiertenkollegs 1034 mit dem Ziel, vielschichtigen Mechanismen der Krebsentstehung, aber auch der individuellen Behandlung von Krebserkrankungen zum Wohle der Betroffenen besser zu verstehen.

Publications

• Onkogenomische Aspekte Zytokin-assoziierter Signaltransduktion, Dissertation Georg-August-Universität Göttingen, 2008
  Schoof, Nils
  
• STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis. Leukemia 2005; 19: 936-44
  Holtick U, Vockerodt M, Pinkert D, Schoof N, Stürzenhofecker B, Kussebi N, Lauber K, Wesselborg S, Löffler D, Horn F, Trümper L, Kube D
  
• The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation. Int J Cancer 2005; 114: 598-605
  Vockerodt M, Pinkert D, Smola-Hess S, Michels A, Ransohoff RM, Tesch H, Kube D
  
• Genetische Variabilität im Serotonin 5-HT3-Rezeptor, Dissertation Technische Universität Braunschweig, 2006
  Meineke, Cornelia
  
• Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEAS treatment in adrenocortical cells. Am. J. Physiol. Endocrin. Metab. 2006; 291: E1351-E1359
  Asif AR, Ljubojevic M, Sabolic I, Shnitsar V, Metten M, Anazi N, Müller GA, Burckhardt G, Hagos Y
  
• Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter. Biochem J 2006; 393: 79-87
  Petry F, Ritz V, Meineke C, Middel P, Kietzmann T, Schmitz-Salue C, Hirsch-Ernst KI
  
• (2007) Lessons learned from DNA repair defective syndromes. Exp Dermatol. 16(6):532-544
  Thoms KM, Kuschal C, Emmert S
  
• (2007) Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. GENE, 386(1-2): 52-62
  Tzvetkov MV, Meineke C, Oetjen E, Hirsch-Ernst K, Brockmöller J
  
• 2007. The proepicardium delivers hemangioblasts but not lymphangioblasts to the developing heart. Dev Biol 2007; 305:451-59
  Wilting, J., Buttler, K., Schulte, I., Papoutsi, M., Schweigerer, L., Manner, J.
  
• Association between the BclI glucocorticoid receptor polymorphism and smoking in a sample of patients with obstructive airway disease. Addict Biol 2007: 12: 93-9
  Rogausch A, Kochen MM, Meineke C, Hennig J
  
• Development and implementation of an analysis tool for arraybased comparative genomic hybridization. Methods Inf Med. 2007;46: 608–13
  Kreuz M, Rosolowski M, Berger H, Schwaenen C, Wessendorf S, Loeffler M, Hasenclever D
  
• Embryonic development of the lymphovascular system and tumor lymphangiogenesis. Cancer Treat Res 2007; 135:17-24
  Wilting, J., Papoutsi, M., Buttler, K., Becker, J
  
• Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1, Dissertation Georg-August-Universität Göttingen, 2007
  Pinkert-Leetsch, Diana
  
• Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan. Pharmacogenet Genom 2007; 17: 505-17
  Kühne A, Kaiser R, Schirmer M, Heider U, Muhlke S, Niere W, Overbeck T, Hohloch K, Trümper L, Sezer O, Brockmöller J
  
• Genotyping and segregation analyses indicate the presence of only two functional MIC genes in rhesus macaques. Immunogenetics 2007; 59: 247-51
  Averdam A, Seelke S, Grützner I, Rosner C, Roos C, Westphal N, Stahl-Hennig C, Muppala V, Schrod A, Sauermann U, Dressel R, Walter L
  
• Issues in association mapping with high-density SNP data and diverse family structures. Genet Epidemiol 2007; 31: S22-33
  Bickeböller H, Goddard KA, Igo RP, Kraft P, Lozano JP, Pankratz N, Balavarca Y, Bardel C, Charoen P, Croiseau P, Guo CY, Joo J, Köhler K, Madsen A, Malzahn D, Monsees G, Sohns M, Ye Z
  
• Issues in association mapping with highdensity SNP data and diverse family structures. Genet Epi 2007; 31 (Supplement 1): S22-S33
  Bickeböller H, Goddard KAB, Igo RP, Kraft P, Lozano JP, Prankratz N
  
• Live Cell FRET Microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3).J Biol Chem, 2007; 282: 26997-7005
  M. Hillebrand, S. E. Verrier, A. Ohlenbusch, A. Schäfer, H.-D. Söling, F. S. Wouters, J. Gärtner
  
• The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands. J Immunol 2007; 179: 5523-33
  Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeböller H, Brunner E, Zientkowska M, Herrmann T, Walter L, Alves F, Multhoff G, Dressel R
  
• (2008) Correlation of Hsp70-1 and Hsp70-2 Gene Expression With the Degree of Graft-Versus-Host Reaction in a Rat Skin Explant Model. Transplantation, 85(12): 1809-1816
  Novota P, Sviland L, Zinöcker S, Stocki P, Balavarca Y, Bickeböller H, Rolstad B, Wang XN, Dickinson AM, Dressel R
  
• (2008) Cyclopamine treatment of full-blown Hh/Ptchassociated RMS partially inhibits Hh/Ptch signaling, but not tumor growth. Mol Carcinogen, 47(5): 361-72
  Ecke I, Rosenberger A, Obenauer S, Dullin C, Aberger F, Kimmina S, Schweyer S, Hahn H
  
• (2008) Dynamics in the p38alpha MAP kinase-SB203580 complex observed by liquidstate NMR spectroscopy. Angew Chem Int Ed Engl. 2008;47(19):3548-51
  Honndorf VS, Coudevylle N, Laufer S, Becker S, Griesinger C
  
• (2008) Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study. Clin Cancer Res, 14(12): 3777-84
  Kube D, Hua TD, von Bonin F, Schoof N, Zeynalova S, Klöss M, Gocht D, Potthoff B, Tzvetkov M, Brockmöller J, Löffler M, Pfreundschuh M, Trümper L
  
• (2008) Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene. Pharmacogenet Genom, 18(3): 219-30
  Meineke C, Tzvetkov MV, Bokelmann K, Oetjen E, Hirsch-Ernst K, Kaiser R, Brockmöller J
  
• (2008) Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. Brit J Haematol, 142(3): 436-443
  Ludajic K, Balavarca Y, Bickeböller H, Pohlreich D, Kouba M, Dobrovolna M, Vrana M, Rosenmayr A, Fischer GF, Fae I, Kalhs P, Greinix HT
  
• (2008) Keratoepithelin reverts the suppression of tissue factor pathway inhibitor 2 by MYCN in human neuroblastoma: a mechanism to inhibit invasion. Int J Oncol.;32(1):235-40
  Becker J, Volland S, Noskova I, Schramm A, Schweigerer LL, Wilting J
  
• (2008) Population pharmacokinetics of melphalan and glutathione S-transferase polymorphisms in relation to side effects. Clin Pharmacol Ther, 83(5): 749-57
  Kühne A, Sezer O, Heider U, Meineke I, Muhlke S, Niere W, Overbeck T, Hohloch K, Trümper L, Brockmöller J, Kaiser R
  
• (2008). Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity. Pharmacogenomics J. 8(4):297-304
  Schirmer M, Hoffmann M, Kaya E, Tzvetkov M, Brockmöller J
  
• (2008). The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 83(6):815-7
  Vormfelde SV, Toliat MR, Schirmer M, Meineke I, Nürnberg P, Brockmöller J
  
• Immungenetische Marker im Wandel der Zeit: Molekulargenetische Analyse von single nucleotide Polymorphismen immungenetischer Rezeptoren und Interleukine in historischen Bevölkerungen, Dissertation Georg-August-Universität Göttingen, 2008
  Pepperl, geb. Pollmann, Jutta
  
• MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians. BMC Cancer. 2008 Apr 23;8:116
  Bittenbring J, Parisot F, Wabo A, Mueller M, Kerschenmeyer L, Kreuz M, Truemper L, Landt O, Menzel A, Pfreundschuh M, Roemer K
  
• Pharmakogenetik des Zytostatikums Melphalan: Charakterisierung des Membrantransportes, Dissertation Georg-August-Universität Göttingen, 2008
  Kühne, Annett
  
• Polymorphism of heat schock receptors, Dissertation Georg-August-Universität Göttingen, 2008
  Muppala, Vijayakumar
  
• Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics. BMC Dev Biol 2008; 8:43
  Buttler, K., Ezaki, T., Wilting, J.
  
• Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma. Haematologica. 2008 Jun;93(6):949– 50
  Nieländer I, Martín-Subero JI, Wagner F, Baudis M, Gesk S, Harder L, Hasenclever D, Klapper W, Kreuz M, Pott C, Martinez-Climent JA, Dreyling M, Arnold N, Siebert R
  
• The expression of polyspecific transporters in renal tumors and their role in chemotherapeutical treatment, Dissertation Georg-August-Universität Göttingen, 2008
  Shnitsar, Vladimir M.
  
• Untersuchtung von P38α-MAP-Kinase/Inhibitor- Komplexen in Lösung mittels Kernspinspektroskopie, Dissertation Philips-Universität Marburg, 2008
  Honndorf, Valerie
  
• Überprüfung neuer Therapieansätze für Patched-assoziierte Tumoren im Mausmodell, Dissertation Georg-August-Universität Göttingen, 2008
  Ecke, Ines
  
• (2009) Activity of NAD(P)H oxidase in relation to genotypes: comprehensive genetic mapping of single nucleotide polymorphisms (SNPs) in the p22(phox) subunit. Int J Clin Pharm TH, 47(1): 41-3
  Hoffmann M, Schirmer M, Tzvetkov M, Brockmoeller J
  
• (2009) Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. Cancer Res, 69(3): 887-95
  Ecke I, Petry F, Rosenberger A, Tauber S, Mönkemeyer S, Hess I, Dullin C, Kimmina S, Pirngruber J, Johnsen Steven A, Uhmann A, Nitzki F, Wojnowski L, Schulz-Schaeffer W, Witt O, Hahn H
  
• (2009) Association of HLA-E polymorphism with the outcome of hematopoietic stem-cell transplantation with unrelated donors. Transplantation, 88(10): 1227-8
  Ludajic K, Rosenmayr A, Faé I, Fischer GF, Balavarca Y, Bickeböller H, Kalhs P, Greinix HT
  
• (2009) Bioinformatic and functional analysis of TGFBR1 polymorphisms. Pharmacogenet Genom, 19(4): 249-59
  Schirmer MA, Hoffmann AO, Campean R, Janke JH, Zidek LM, Hoffmann M, Kruse M, Sehrt D, Tzvetkov MV, Rave-Fränk M, Brockmöller J
  
• (2009) CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. Embo Rep, 10(8): 894-900
  Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman RD, Eick D, Aylon Y, Oren M, Johnsen SA
  
• (2009) Characterization of transcriptional regulation of 5-HT3B in rat PC-12 cells: the role of glucocorticoids. Int J Clin Pharm TH, 47(1): 36-7
  Bokelmann K, Brockmoeller J, Tzvetkov MV
  
• (2009) Cyclosporin A, but not everolimus, inhibits DNA repair in human fibroblasts and lymphoblasts. Int J Clin Pharm TH, 47(1): 38-40
  Kuschal C, Thoms KM, Mori T, Kobayashi N, Boeckmann L, Laspe P, Emmert S
  
• (2009) Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study. Genes Immun, 10(6): 586-90
  Schoof N, von Bonin F, König IR, Mössner R, Krüger U, Reich K, Berking C, Volkenandt M, Ziegler A, Böckmann L, Kuschal C, Thoms KM, Kube D, Emmert S
  
• (2009) Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians. Pharmacogenet Genom, 19(10): 760-9
  Boeckmann L, Schirmer M, Rosenberger A, Struever D, Thoms KM, Gutzmer R, Has C, Kunz M, Kuschal C, Laspe P, Schoen M, Brockmoeller J, Emmert S
  
• (2009) Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine. Cancer Res, 69(4): 1494-501
  Shnitsar V, Eckardt R, Gupta S, Grottker J, Müller GA, Koepsell H, Burckhardt G, Hagos Y
  
• (2009) Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial. Ann Oncol, 20(9): 1548-54
  Schoof N, von Bonin F, Zeynalova S, Ziepert M, Jung W, Loeffler M, Pfreundschuh M, Trümper L, Kube D
  
• (2009) HSP90 is essential for Jak- STAT signaling in classical Hodgkin lymphoma cells. Cell Commun Signal, 7: 17
  Schoof N, von Bonin F, Trümper L, Kube D
  
• (2009) Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines. Biochem Pharmacol, 78(1): 45-53
  Kühne A, Tzvetkov MV, Hagos Y, Lage H, Burckhardt G, Brockmöller J
  
• (2009) Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. Cell Cycle, 8(22): 3636-42
  Pirngruber J, Shchebet A, Johnsen S
  
• (2009) KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation. Bone Marrow Transpl, 44: 97-103
  Ludajic K, Balavarca Y, Bickeböller H, Rosenmayr A, Fae I, Fischer GF, Kouba M, Pohlreich D, Kalhs P, Greinix HT
  
• (2009) Minor ABO- mismatches are risk factors for acute graft-versus-host disease in hematopoietic stem cell transplant patients. Biol Blood Marrow Tr, 15(11): 1400-6
  Ludajic K, Balavarca Y, Bickeböller H, Rosenmayr A, Fischer GF, Faé I, Kalhs P, Pohlreich D, Kouba M, Dobrovolna M, Greinix HT
  
• (2009) Modulation of the efficacy of temozolomide and dacarbazine melanoma treatment by DNA-repair factors in vivo and in vitro. Int J Clin Pharm TH, 47(1): 33-5
  Boeckmann L, Thoms KM, Gutzmer R, Has C, Kunz M, Kuschal C, Laspe P, Struever D, Emmert S
  
• (2009) Possible changes in the genomic features of tumor tissues over the last 150 years. J Clin Pharmacol Therapeut 47 (1): 44-45
  Schmücker K, Herrmann B, Hummel S
  
• (2009) Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. Int J Cancer;125(9):2049-57
  Volland S, Kugler W, Schweigerer L, Wilting J, Becker J
  
• (2009) Strict sun protection results in minimal skin changes in a patient with xeroderma pigmentosum and a novel c.2009delG mutation in XPD (ERCC2). Exp Dermatol, 18(1): 64-8
  Emmert S, Ueda T, Zumsteg U, Weber P, Khan Sikandar G, Oh KS, Boyle J, Laspe P, Zachmann K, Boeckmann L, Kuschal C, Bircher A, Kraemer Kenneth H
  
• (2009) Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort. BMC Proc, 3(7): S80
  Malzahn D, Balavarca Y, Lozano JP, Bickeböller H
  
• (2009). Faecal calprotectin and lactoferrin values during irradiation of prostate cancer correlate with chronic radiation proctitis: results of a prospective study. Scand J Gastroenterol. 44(8):939-46
  Hille A, Rave-Fränk M, Christiansen H, Herrmann MK, Kertesz T, Hermann RM, Wolff HA, Schirmer M, Hess CF, Ramadori G
  
• (2009). The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clinical pharmacology and therapeutics 86: 299-306
  Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, et al.
  
• Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma. Leukemia. 2009 Oct;23(10):1875–84
  Schwindt H, Vater I, Kreuz M, Montesinos-Rongen M, Brunn A, Richter J, Gesk S, Ammerpohl O, Wiestler OD, Hasenclever D, Deckert M, Siebert R
  
• Der Protein-Tyrosin-Kinase-Rezeptor TRKB reguliert das Hepatocyte-growth-factor-, c-Met-Signalsystem in humanen Neuroblastomzellen : molekulare, biologische und klinische Implikationen, Dissertation Georg-August-Universität Göttingen, 2009
  Tran, Dinh-Hoa
  
• Die Bedeutung von Stanniocalcin 2 im humanen Neuroblastom, Dissertation Georg-August-Universität Göttingen, 2009
  Volland, Sonja
  
• Einfluss der Immunsuppressiva Cyclosporin A und Everolimus auf die funktionelle DNA Reparaturfähigkeit sowie auf die Regulation von DNA-Reparatur-Genen, Dissertation Georg-August-Universität Göttingen, 2009
  Kuschal, Christiane
  
• Expression of SLC transporters in CLL cells and their interaction with cytostatics, Dissertation Georg-August-Universität Göttingen, 2009
  Gupta, Shivangi
  
• GeneChip analyses point to novel pathogenetic mechanisms in mantle cell lymphoma. Br J Haematol. 2009 Feb;144(3):317–31
  Vater I, Wagner F, Kreuz M, Berger H, Martín-Subero JI, Pott C, Martinez- Climent JA, Klapper W, Krause K, Dyer MJ, Gesk S, Harder L, Zamo A, Dreyling M, Hasenclever D, Arnold N, Siebert R
  
• Genetische Variabilität in der phagozytären NAD(P)H-Oxidase: Funktionelle Charakterisierung und Bedeutung für die Zytostatika-Therapie, Dissertation Georg-August-Universität Göttingen, 2009
  Hoffmann, Marion
  
• Interindividual variation in the pharmacokinetics of Delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9. Clin Pharmacol Ther. 2009; 85: 273-6
  Sachse-Seeboth C, Pfeil J, Sehrt D, Meineke I, Tzvetkov M, Bruns E, Poser W, Vormfelde SV, Brockmöller J
  
• Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe; Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status. Genes Chromosomes Cancer. 2009 Jan;48(1):39–54
  Schwaenen C, Viardot A, Berger H, Barth TF, Bentink S, Döhner H, Enz M, Feller AC, Hansmann ML, Hummel M, Kestler HA, Klapper W, Kreuz M, Lenze D, Loeffler M, Möller P, Müller-Hermelink HK, Ott G, Rosolowski M, Rosenwald A, Ruf S, Siebert R, Spang R, Stein H, Truemper L, Lichter P, Bentz M, Wessendorf S
  
• Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe; New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood. 2009 Mar 12;113(11):2488–97
  Martín-Subero JI, Kreuz M, Bibikova M, Bentink S, Ammerpohl O, Wickham-Garcia E, Rosolowski M, Richter J, Lopez-Serra L, Ballestar E, Berger H, Agirre X, Bernd HW, Calvanese V, Cogliatti SB, Drexler HG, Fan JB, Fraga MF, Hansmann ML, Hummel M, Klapper W, Korn B, Küppers R, Macleod RA, Möller P, Ott G, Pott C, Prosper F, Rosenwald A, Schwaenen C, Schübeler D, Seifert M, Stürzenhofecker B, Weber M, Wessendorf S, Loeffler M, Trümper L, Stein H, Spang R, Esteller M, Barker D, Hasenclever D, Siebert R
  
• Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. Nature Immunology 2009; 10:1018-25
  Engels N, König L, Heemann C, Lutz J, Tsubata T, Griep S, Schrader V, Wienands J
  
• Role of heat schock protein 70 and sulphatases 1 and 2 in apoptosis induced by cytotoxic cells of the immune system, Dissertation Georg-August-Universität Göttingen, 2009
  Nussbeck, geb. Demiroglu, Sara Yasemin
  
• (2010) A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma. Cancer Res, 70(6): 2328-38
  Hoffmann M, Schirmer MA, Tzvetkov MV, Kreuz M, Ziepert M, Wojnowski L, Kube D, Pfreundschuh M, Trümper L, Loeffler M, Brockmöller J
  
• (2010) Enhanced T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma cells. Exp Dermatol, 19(2): 108-16
  Knudsen S, Schardt A, Buhl T, Boeckmann L, Schön MP, Neumann C, Haenssle HA
  
• (2010) Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. Haematol-Hematol J, 95(6): 922-7
  Dickinson AM, Pearce KF, Norden J, O'Brien SG, Holler E, Bickeböller H, Balavarca Y, Rocha V, Kolb HJ, Hromadnikova I, Sedlacek P, Niederwieser D, Brand R, Ruutu T, Apperley J, Szydlo R, Goulmy E, Siegert W, de Witte T, Gratwohl A
  
• (2010) The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells. J Cell Mol Med, 14(4): 992-1002
  Elsner L, Flügge PF, Lozano J, Muppala V, Eiz-Vesper B, Demiroglu SY, Malzahn D, Herrmann T, Brunner E, Bickeböller H, Multhoff G, Walter L, Dressel R
  
• (2010) The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability. Pharmacogenetics and genomics 20(3), 167-178
  Qiu, H., Mathäs, M., Nestler, S., Bengel, C., Nem, D., Godtel-Armbrust, U., Lang, T., Taudien, S., Burk, O. and Wojnowski, L.
  
• (2010) Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII. Cancer Res, 70(7): 2739-48
  Nitzki F, Zibat A, König S, Wijgerde M, Rosenberger A, Brembeck FH, Carstens PO, Frommhold A, Uhmann A, Klingler S, Reifenberger J, Pukrop T, Aberger F, Schulz-Schaeffer W, Hahn H
  
• (2010). Amelogenin-based sex identification as a strategy to control the identity of DNA samples in genetic association studies. Pharmacogenomics 11: 449-457
  Tzvetkov MV, Meineke I, Sehrt D, Vormfelde SV, Brockmöller J
  
• (2010). Helix-hairpin-helix protein MJ1434 from Methanocaldococcus jannaschii and EndoIV homologue TTC0482 from Thermus thermophilus HB27 do not process DNA uracil residues. Nucleic Acids Research 38 (15), 5119– 5129
  Schomacher, L., Smolorz, S., Ciirdaeva, E., Ber, S., Kramer, W. and Fritz, H.- J.
  
• (2010). High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathologic tumor regression in multimodal treatment of locally advanced rectal cancer. Strahlenther Onkol. 186(1):30-5
  Wolff HA, Gaedcke J, Jung K, Hermann RM, Rothe H, Schirmer M, Liersch T, Herrmann MK, Hennies S, Rave-Fränk M, Hess CF, Christiansen H
  
• (2010). KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy. Radiother Oncol. 94(1):76-81
  Gaedcke J, Grade M, Jung K, Schirmer M, Jo P, Obermeyer C, Wolff HA, Herrmann MK, Beissbarth T, Becker H, Ried T, Ghadimi M
  
• (2010). Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. Genes Chromosomes Cancer. 49(11):1024-34
  Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM
  
• A novel phosphatase modulating the DNA damage response and the tumor suppressor p53, Dissertation Georg-August-Universität Göttingen, 2010
  Marinoglou, Konstantina
  
• Gene dosage effects in chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2010 Dec;203(2):149-60
  Sellmann L, Scholtysik R, Kreuz M, Cyrull S, Tiacci E, Stanelle J, Carpinteiro A, Nückel H, Boes T, Gesk S, Siebert R, Klein-Hitpass L, Dührsen U, Dürig J, Küppers R
  
• Generalized Quantitative Transmission Disequilibrium Test for Analyzing Genetic Main Effects and Epistasis, Dissertation Georg-August-Universität Göttingen, 2010
  Lozano, Jingky
  
• Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome. Am J Hum Genet. 2010 Feb 12;86(2):279–84
  Schneppenheim R, Frühwald MC, Gesk S, Hasselblatt M, Jeibmann A, Kordes U, Kreuz M, Leuschner I, Martin Subero JI, Obser T, Oyen F, Vater I, Siebert R
  
• High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus. Br J Haematol. 2010 Feb;148(3):402–12
  Hartmann S, Gesk S, Scholtysik R, Kreuz M, Bug S, Vater I, Döring C, Cogliatti S, Parrens M, Merlio JP, Kwiecinska A, Porwit A, Piccaluga PP, Pileri S, Hoefler G, Küppers R, Siebert R, Hansmann ML
  
• Molecular Mechanisms in Malignant Lymphomas Network Project of Deutsche Krebshilfe; Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis. Haematologica. 2010 Dec;95(12):2047–55
  Scholtysik R, Kreuz M, Klapper W, Burkhardt B, Feller AC, Hummel M, Loeffler M, Rosolowski M, Schwaenen C, Spang R, Stein H, Thorns C, Trümper L, Vater I, Wessendorf S, Zenz T, Siebert R, Küppers R
  
• Orale Antikoagulantien. Deutsche Apotheker Zeitung 32, 2010
  M. Abu Abed, T.D. Hua, J.F. Chenot, S.V. Vormfelde
  
• Orale Antikoagulation in der Hausarztpraxis. Zeitschrift für Allgemeinmedizin 10, 2010
  T. D. Hua, S.V. Vormfelde, M. Abu Abed, H. Schneider-Rudt, P. Sobotta, J.F. Chenot
  
• Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur, Dissertation Georg-August-Universität Göttingen, 2010
  Böckmann, Lars
  
• (2011) Cyclosporin A inhibits nucleotide excision repair via downregulation of the xeroderma pigmentosum group A and G proteins, which is mediated by calcineurin inhibition. Exp Dermatol, 20(10): 795-9
  Kuschal C, Thoms KM, Boeckmann L, Laspe P, Apel A, Schön MP, Emmert S
  
• (2011) Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3. Am J Physiol Renal Physiol. 301(5):F1026-34
  Kaufhold M, Schulz K, Breljak D, Gupta S, Henjakovic M, Krick W, Hagos Y, Sabolic I, Burckhardt BC, Burckhardt G
  
• (2011) Down-regulation of BLIMP1? by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas. Blood, 117(22): 5907- 17
  Vrzalikova K, Vockerodt M, Leonard S, Bell A, Wei W, Schrader A, Wright KL, Kube D, Rowe M, Woodman CB, Murray PG
  
• (2011) Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol. Clin Pharmacol Ther, 90(1): 143-50
  Tzvetkov MV, Saadatmand AR, Lötsch J, Tegeder I, Stingl JC, Brockmöller J
  
• (2011) Genomic data integration using guided clustering. Bioinformatics, 27(16): 2231-8
  Maneck M, Schrader A, Kube D, Spang R
  
• (2011) High Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas. Int J Cancer, 131(4): E348-61
  Schrader A, Bentink S, Spang R, Lenze D, Hummel M, Kuo M, Arrand JR, Murray PG, Trümper L, Kube D, Vockerodt M
  
• (2011) Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents. Drug Metabol Drug Interact, 26(4): 181-9
  Grottker J, Rosenberger A, Burckhardt G, Hagos Y
  
• (2011) Practice nursed-based, individual and video-assisted patient education in oral anticoagulation: protocol of a cluster-randomized controlled trial. Bmc Fam Pract, 12(1): 17
  Hua TD, Vormfelde SV, Abed MA, Schneider-Rudt H, Sobotta P, Friede T, Chenot JF
  
• (2011) Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region. Immunogenetics. 63(2):85-93
  Averdam A, Kuschal C, Otto N, Westphal N, Roos C, Reinhardt R, Walter L
  
• (2011) SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells. Biol Chem. 392(1-2):117-24
  Gupta S, Burckhardt G, Hagos Y
  
• (2011) Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution. Melanoma Res, 21(3): 206-16
  Boeckmann L, Nickel AC, Kuschal C, Schaefer A, Thoms KM, Schön MP, Thomale J, Emmert S
  
• (2011) The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. Cell Cycle, 10(20): 3495-504
  Kari V, Shchebet A, Neumann H, Johnsen SA
  
• (2011). Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Radiat Environ Biophys 50(1):145-54
  Wolff HA, Rolke D, Rave-Fränk M, Schirmer M, Eicheler W, Doerfler A, Hille A, Hess CF, Matthias C, Rödel RM, Christiansen H
  
• (2011). Comparison of the micronucleus and chromosome aberration techniques for the documentation of cytogenetic damage in radiochemotherapy-treated patients with rectal cancer. Strahlenther Onkol. 187: 52-8
  Wolff HA, Hennies S, Herrmann MK, Rave-Fränk M, Eickelmann D, Virsik P, Jung K, Schirmer M, Ghadimi M, Hess CF, Hermann RM, Christiansen H
  
• (2011). Genderspecific acute organ toxicity during intensified preoperative radiochemotherapy for rectal cancer. Oncologist. 16(5):621-31
  Wolff HA, Conradi LC, Schirmer M, Beissbarth T, Sprenger T, Rave-Fränk M, Hennies S, Hess CF, Becker H, Christiansen H, Liersch T
  
• (2011). Novel Carcinoembryonic-Antigen-(CEA)-Specific Pretargeting System to Assess Tumor Cell Viability after Irradiation of Colorectal Cancer Cells. Strahlenther Onkol. 187(2):120-6
  Meller B, Rave-Fränck M, Breunig C, Schirmer M, Baehre M, Nadrowitz R, Liersch T, Meller J
  
• (2011). Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment. Ann Surg Oncol. 18(9):2442-52
  Conradi LC, Bleckmann A, Schirmer M, Sprenger T, Jo P, Homayounfar K, Wolff HA, Rothe H, Middel P, Becker H, Ghadimi MB, Beissbarth T, Liersch T
  
• A putatively functional haplotype in the gene encoding transforming growth factor beta-1 as a potential biomarker for radiosensitivity. Int J Radiat Oncol Biol Phys. 2011;79: 866-74
  Schirmer MA, Brockmöller J, Rave-Fränk M, Virsik P, Wilken B, Kühnle E, Campean R, Hoffmann AO, Müller K, Goetze RG, Neumann M, Janke JH, Nasser F, Wolff HA, Ghadimi BM, Schmidberger H, Hess CF, Christiansen H, Hille A
  
• Charakterisierung des 5-HT3B-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus, Dissertation Georg-August-Universität Göttingen, 2011
  Bokelmann, Kristin
  
• Cyclosporin A, but not everolimus, inhibits DNA repair mediated by calcineurin: implications for tumorigenesis under immunosuppression. Exp Dermatol 2011; 20: 232-6
  Thoms KM, Kuschal C, Oetjen E, Mori T, Kobayashi N, Laspe P, Boeckmann L, Schön MP, Emmert S
  
• Expression von SLC-Transportern in Melanomzelllinien und Charakterisierung von MATE1 und OCT1 in ihrer Funktion als Zytostatikatransporter, Dissertation Georg-August-Universität Göttingen, 2011
  Grottker, Julia
  
• Identification and functional characterization of oncogenic pathway signatures in malignant lymphoma, Dissertation Georg-August-Universität Göttingen, 2011
  Schrader, Alexandra
  
• Identification of genomic alterations associated with metastasis and cancer specific survival in clear cell renal cell carcinoma. J Urol. 2011 Nov;186(5):2078–83
  Sanjmyatav J, Junker K, Matthes S, Muehr M, Sava D, Sternal M, Wessendorf S, Kreuz M, Gajda M, Wunderlich H, Schwaenen C
  
• Identifikation von Mutationen im Tumorsuppressorgen p53 und des Bakteriums Helicobacter pylori in Magenkarzinomen histopathologischer Präparate aus verschiedenen medizinhistorischen Sammlungen, Dissertation Georg-August-Universität Göttingen, 2011
  Licht, geb. Schmücker, Katharina
  
• Onkogenomische Aspekte Zytokin-assoziierter Signaltransduktion, Dissertation Georg-August-Universität Göttingen, 2011
  Shchebet, Andrei
  
• Pharmacogenetic analyses of cisplatin-induced nephrotoxicity indicate a renoprotective effect of ERCC1 polymorphisms. Pharmacogenomics 2011; 12: 1417-1427
  Tzvetkov MV, Behrens G, O'Brien VP, Hohloch K, Brockmöller J, Benöhr P
  
• Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution. Melanoma research, 2011; 21: 206-216
  L. Boeckmann, A.-C. Nickel, C. Kuschal, A. Schäfer, K.-M. Thoms, M. P. Schön, J. Thomale, S. Emmert
  
• The impact of Fc-γ receptor polymorphisms in elderly patients with diffuse large B-cell lymphoma treated with CHOP with or without rituximab. Blood. 2011 Oct 27;118(17):4657–62
  Ahlgrimm M, Pfreundschuh M, Kreuz M, Regitz E, Preuss KD, Bittenbring J
  
• Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults. Blood. 2011;118: 139–147
  Salaverria I, Philipp C, Oschlies I, Kohler CW, Kreuz M, Szczepanowski M, Burkhardt B, Trautmann H, Gesk S, Andrusiewicz M, Berger H, Fey M, Harder L, Hasenclever D, Hummel M, Loeffler M, Mahn F, Martin-Guerrero I, Pellissery S, Pott C, Pfreundschuh M, Reiter A, Richter J, Rosolowski M, Schwaenen C, Stein H, Trümper L, Wessendorf S, Spang R, Küppers R, Klapper W, Siebert R
  
• (2012) Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma. Clin Cancer Res, 2012; 18: 3637-47
  Heemann C, Kreuz M, Stoller I, Schoof N, von Bonin F, Ziepert M, Löffler M, Jung W, Pfreundschuh M, Trümper L, Kube D
  (See online at https://doi.org/10.1158/1078-0432.CCR-11-3299)
• (2012) Contribution to the molecular phylogenetic analysis of extant holocephalan fishes (Holocephali, Chimaeriformes). Org Divers Evol
  Licht M, Schmücker K, Hanel R, Bartsch P, Paeckert M
  (See online at https://doi.org/10.1007/s13127-011-0071-1)
• (2012) Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron. Pharmacogenomics J, 12(1): 22-9
  Tzvetkov MV, Saadatmand AR, Bokelmann K, Meineke I, Kaiser R, Brockmöller J
  (See online at https://doi.org/10.1038/tpj.2010.75)
• (2012) Evolutionary History and Functional Characterization of the Amphibian Xenosensor CAR. Mol Endocrinol 26(1), 14-26
  Mathäs, M., Burk, O., Qiu, H., Nusshag, C., Godtel-Armbrust, U., Baranyai, D., Deng, S., Romer, K., Nem, D., Windshugel, B. and Wojnowski, L.
  (See online at https://doi.org/10.1210/me.2011-1235)
• (2012) Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas. Cell Commun Signal, 10(1): 43.
  Schrader A, Meyer K, von Bonin F, Vockerodt M, Walther N, Hand E, Ulrich A, Matulewicz K, Lenze D, Hummel M, Kieser A, Engelke M, Trümper L, Kube D
  (See online at https://doi.org/10.1186/1478-811X-10-43)
• (2012) Human organic cation transporter 1 is expressed in lymphoma cells and increases susceptibility to irinotecan and paclitaxel. J Pharmacol Exp Ther. 341:16-23
  Gupta S, Wulf G, Henjakovic M, Koepsell H, Burckhardt G, Hagos Y
  (See online at https://doi.org/10.1124/jpet.111.190561)
• (2012) No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study. Arch Dermatol Res, 304(5): 353-61
  Schäfer A, Emmert S, Kruppa J, Schubert S, Tzvetkov M, Mössner R, Reich K, Berking C, Volkenandt M, Pföhler C, Schön MP, Vogt T, König IR, Reichrath J
  (See online at https://doi.org/10.1007/s00403-012-1243-3)
• (2012) Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. Cell Cycle, 11(11): 2122-7
  Shchebet A, Karpiuk O, Kremmer E, Eick D, Johnsen SA
  (See online at https://doi.org/10.4161/cc.20548)
• (2012) PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells. PLoS One;7(12): Epub 2012 Dec 31
  Marklein D, Graab U, Naumann I, Yan T, Ridzewski R, Nitzki F, Rosenberger A, Dittmann K, Wienands J, Wojnowski L, Fulda S, Hahn H
  (See online at https://doi.org/10.1371/journal.pone.0052898)
• (2012) Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair. Exp Dermatol, 21(1): 2-6
  Kuschal C, Thoms KM, Schubert S, Schäfer A, Boeckmann L, Schön MP, Emmert S
  
• (2012) The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Mol Cell, 46(5): 705-13
  Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA
  (See online at https://doi.org/10.1016/j.molcel.2012.05.022)
• (2012) The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1. Biochem Pharmacol, 83(10): 1427-34
  Saadatmand AR, Tadjerpisheh S, Brockmöller J, Tzvetkov MV
  (See online at https://doi.org/10.1016/j.bcp.2012.01.032)
• (2012) The role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotection. Yale J Biol Med. 2012 Dec;85(4):469-80
  Marinoglou K
  
• (2012). Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant. Int J Radiat Oncol Biol Phys. 83(1):149-57
  Schirmer MA, Mergler CP, Rave-Fränk M, Herrmann MK, Hennies S, Gaedcke J, Conradi LC, Jo P, Beissbarth T, Hess CF, Becker H, Ghadimi M, Brockmöller J, Christiansen H, Wolff HA
  (See online at https://doi.org/10.1016/j.ijrobp.2011.05.063)
• (2012). In regard to "Thymidylate synthase gene polymorphism affects the response to preoperative 5-fluorouracil chemoradiation therapy in patients with rectal cancer" (Int J Radiat Oncol Biol Phys 2011;81:669-676). Int J Radiat Oncol Biol Phys. 82(3):1058
  Schirmer MA, Wolff HA, Conradi LC, Christiansen H
  
• (2012). No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study. Archives of dermatological research 304: 353-361
  Schäfer A, Emmert S, Kruppa J, Schubert S, Tzvetkov M, Mössner R, et al.
  (See online at https://doi.org/10.1007/s00403-012-1243-3)
• Assessing prediction error of genetic variants in Cox regression models, Dissertation Georg-August-Universität Göttingen, 2012
  Balavarca, Yesilda
  
• Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma. Clinical cancer research 2012; 18: 3637–47
  Heemann C, Kreuz M, Stoller I, Schoof N, von Bonin F, Ziepert M, et al.
  (See online at https://doi.org/10.1158/1078-0432.CCR-11-3299)
• Die Rolle von Wnt5a bei der Regression des Basalzellkarzinoms, Dissertation Georg-August-Universität Göttingen, 2012
  König, Simone
  
• Identification of a new fatty acid synthesis-transport machinery at the peroxisomal membrane. J Biol Chem, 2012; 287: 210-221
  M. Hillebrand, S. W. Gersting, A. S. Lotz-Havla, A. Schäfer, H. Rosewich, O. Valerius, A. C. Muntau, J. Gärtner
  (See online at https://doi.org/10.1074/jbc.M111.272732)
• Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations. Experimental Dermatology, 2012; 22: 24-9
  A. Schäfer, L. Hofmann, A. Gratchev, P. Laspe, S. Schubert, A. Schürer, A. Ohlenbusch, M. Tzvetkov, C. Hallermann, J. Reichrath, M. P. Schön, S. Emmert
  (See online at https://doi.org/10.1111/exd.12052)
• Multiplex analysis of genetic markers related to body mass index (BMI) and bone mineral density (BMD). Anthropol Anz. 2012; 69:423-38
  Fromm-Dornieden C1, Pepperl J, Herrmann B, Hummel S
  
• No association of vitamin D signaling-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study. Archives for Dermatological Research, 2012; 304: 353-361
  A. Schäfer, L. Hofmann, A. Gratchev, P. Laspe, S. Schubert, A. Schürer, A. Ohlenbusch, M. Tzvetkov, C. Hallermann, J. Reichrath, M. P. Schön, S. Emmert
  (See online at https://doi.org/10.1007/s00403-012-1243-3)
• Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. Blood. 2012 Feb 23; 119(8):1882–7
  Klapper W, Kreuz M* (* Geteilte Erstautorschaft), Kohler CW, Burkhardt B, Szczepanowski M, Salaverria I, Hummel M, Loeffler M, Pellissery S, Woessmann W, Schwänen C, Trümper L, Wessendorf S, Spang R, Hasenclever D, Siebert R
  (See online at https://doi.org/10.1182/blood-2011-10-388470)
• Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas. Int J Cancer. 2012; 131: E830-835
  Scholtysik R, Nagel I, Kreuz M, Vater I, Giefing M, Schwaenen C, Wessendorf S, Trümper L, Loeffler M, Siebert R, Küppers R
  (See online at https://doi.org/10.1002/ijc.27416)
• Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet, 2012.Dec;44(12):1316-20
  Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Moller P, Macleod RA, Pott C, Schreiber S, Trumper L, Loeffler M, Stadler PF, Lichter P, Eils R, Kuppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, and Siebert R
  (See online at https://doi.org/10.1038/ng.2469)
• Sensitivierung von Sarkomzellen gegenüber Doxorubizin, Dissertation Georg-August-Universität Göttingen, 2012
  Marklein, Diana
  
• Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair. Exp Dermatol, 2012; 21: 2-6
  C. Kuschal, K.-M. Thoms, S. Schubert, A. Schäfer, L. Boeckmann, M. P. Schön, S. Emmert
  
• Stimulation and analysis of epistatic interactions between xenobiotics membrane transporters and metabolizing enzymes on biotransformation, pharmacodynamics and toxic effects of drugs and carcinogens, Dissertation Georg-August-Universität Göttingen, 2012
  Saadatmand, Ali Reza
  
• (2013) A subset of histone H2B genes produces polyadenylated mRNAs under a variety of cellular conditions. Plos One, 8(5): e63745
  Kari V, Karpiuk O, Tieg B, Kriegs M, Dikomey E, Krebber H, Begus-Nahrmann Y, Johnsen SA
  (See online at https://doi.org/10.1371/journal.pone.0063745)
• (2013) Empirical hierarchical bayes approach to gene-environment interactions: development and application to genome-wide association studies of lung cancer in TRICL. Genet Epidemiol, 37(6): 551-9
  Sohns M, Viktorova E, Amos CI, Brennan P, Fehringer G, Gaborieau V, Han Y, Heinrich J, Chang-Claude J, Hung RJ, Müller-Nurasyid M, Risch A, Lewinger JP, Thomas DC, Bickeböller H
  (See online at https://doi.org/10.1002/gepi.21741)
• (2013) Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP). Cancer Immunol Immun, 62(10): 1587-97
  König S, Regen T, Dittmann K, Engelke M, Wienands J, Schwendener R, Hanisch UK, Pukrop T, Hahn H
  (See online at https://doi.org/10.1007/s00262-013-1444-4)
• (2013) Functional and molecular genetic analyses of nine newly identified XPD- deficient patients reveal a novel mutation resulting in TTD as well as in XP/CS complex phenotypes. Exp Dermatol, 2013; 22: 486-9
  Schäfer A, Gratchev A, Seebode C, Hofmann L, Schubert S, Laspe P, Apel A, Ohlenbusch A, Tzvetkov M, Weishaupt C, Oji V, Schön MP, Emmert S
  
• (2013) Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene. J Pharmacol Exp Ther, 347(1): 181- 92
  O'Brien VP, Bokelmann K, Ramírez J, Jobst K, Ratain MJ, Brockmöller J, Tzvetkov MV
  (See online at https://doi.org/10.1124/jpet.113.206359)
• (2013) Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma. Oncologist, 18(1): 80-9
  Schoof N, Franklin J, Fürst R, Zander T, von Bonin F, Peyrade F, Trümper L, Diehl V, Engert A, Kube D, Re D
  (See online at https://doi.org/10.1634/theoncologist.2012-0291)
• (2013) Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration. Biochem Pharmacol, 86(5): 666-78
  Tzvetkov MV, dos Santos Pereira JN, Meineke I, Saadatmand AR, Stingl JC, Brockmöller J
  (See online at https://doi.org/10.1016/j.bcp.2013.06.019)
• (2013) Suppression of the LMP2A target gene, EGR-1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle. J Pathol, 230(4): 399-409
  Vockerodt M, Wei W, Nagy E, Prouzova Z, Schrader A, Kube D, Rowe M, Woodman CB, Murray PG
  (See online at https://doi.org/10.1002/path.4198)
• (2013) Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes--potent cisplatin analogues and their trans isomers. J Inorg Biochem, 120: 44-53
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• (2013). Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII. Basic Res Cardiol. 2013 Nov;108(6):385
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• Characterization of 3 XPG-defective patients identifies 3 missense mutations that impair repair and transcription. Journal of Investigative Dermatology, 2013; 133, 1841 - 1849
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• Characterization of three XPG-defective patients identifies three missense mutations that impair repair and transcription. J Invest Dermatol, 2013: 133: 1841-9
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• Functional and molecular genetic analyses of 9 newly identified XPD-deficient patients reveal a novel mutation resulting in TTD as well as in XP/CS complex phenotypes. Experimental Dermatology, 2013; 22, 486-489
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• Functional and molecular genetic analyses of nine newly identified XPD- deficient patients reveal a novel mutation resulting in TTD as well as in XP/CS complex phenotypes. Experimental Dermatology, 2013; 22: 486-489
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• Functional Assessment of Biomarkers in Gemcitabine- Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1, Dissertation Georg-August-Universität Göttingen, 2013
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• High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas. Genes Chromosomes Cancer. 2013; 52:150-5
  Salaverria I, Martin-Guerrero I, Burkhardt B, Kreuz M, Zenz T, Oschlies I, Arnold N, Baudis M, Bens S, García-Orad A, Lisfeld J, Schwaenen C, Szczepanowski M, Wessendorf S, Pfreundschuh M, Trümper L, Klapper W, Siebert R
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• Increased Number of Langerhans Cells in the Epidermis of Diabetic Foot Ulcers Correlates with Healing Outcome. Immunol Res. 2013; 57: 222-8
  Stojadinovic O, Yin N, Lehmann J, Pastar I, Kirsner RS, Tomic-Canic M
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• Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations. Exp Dermatol, 2013; 22: 24-9
  Schäfer A, Hofmann L, Gratchev A, Laspe P, Schubert S, Schürer A, Ohlenbusch A, Tzvetkov M, Hallermann C, Reichrath J, Schön MP, Emmert S
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• Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration. Biochemical Pharmacology 2013; 86: 666-78
  Tzvetkov MV, dos Santos Pereira JN, Meineke I, Saadatmand AR, Stingl JC, Brockmöller
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• Patientenindividualisierte Therapie unter Berücksichtigung verschiedener Aspekte - von der Patientenschulung bis zur Verwendung von molekularen Biomarkern, Dissertation Technische Universität Braunschweig, 2013
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• SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-Cell lymphoma (DLBCL) patients. Oncotarget. 2013;4:35-47
  Schif B, Lennerz JK, Kohler CW, Bentink S, Kreuz M, Melzner I, Ritz O, Trümper L, Loeffler M, Spang R, Möller P
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• The role of RNF40 in nuclear function and regulation, Dissertation Georg-August-Universität Göttingen, 2013
  Kari, Vijaya Lakshmi
  
• The ubiquitin ligase G2E3 modulates cell proliferation, survival and the DNA damage response, Dissertation Georg-August-Universität Göttingen, 2013
  Schmidt, Franziska
  
• Variabilität des Therapieansprechens von Gemcitabin bei Pankreaskarzinom: Identifizierung relevanter Genpolymorphismen, Dissertation Georg-August-Universität Göttingen, 2013
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• (2014) Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. Plos One, 9(4): e93555
  König S, Nitzki F, Uhmann A, Dittmann K, Theiss-Suennemann J, Herrmann M, Reichardt HM, Schwendener R, Pukrop T, Schulz-Schaeffer W, Hahn H
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• (2014) HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma. J Pharm Sci. 2014;103: 3326-34
  Hagos Y, Wegner W, Kuehne A, Floerl S, Marada VV, Burckhardt G, Henjakovic M
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• (2014) Safety relevant knowledge of orally anticoagulated patients without self-monitoring: a baseline survey in primary care. BMC Fam Pract. ;25;15:104
  Chenot JF, Hua TD, Abu Abed M, Schneider-Rudt H, Friede T, Schneider S, Vormfelde SV
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• (2014) Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor. PloS one 9(5), e96263
  Mathäs,M., Nußhag,C., Burk, O., Gödtel-Armbrust,U., Herlyn, H., Wojnowski, L. and Windshügel, B
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• (2014) Video-assisted patient education to modify behavior: a systematic review. Patient Educ Couns.;97(1):16-22
  Abu Abed M, Himmel W, Vormfelde S, Koschack J
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• (2014). Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity. J Antimicrob Chemother. 2014 Jul;69(7):1933-7
  Baranyai D, Muro E, Gödtel-Armbrust U, Schirmer MA, Kisanga E, Diczfalusy U, Fillekes Q, Schuurman R, Burger D, Wojnowski L
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• A novel mutation in the XPA gene results in two truncated protein variants and leads to a severe XP/neurological symptoms phenotype, JEADV, 2014
  J. Lehmann, S. Schubert, A. Schäfer, P. Laspe, H. Hänßle, A. Ohlenbusch, A. Gratchev, S. Emmert
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• A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood. 2014;123:1187-98
  Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M* (* Geteilte Erstautorschaft), Kohler CW, Richter J, Pienkowska-Grela B, Adam P, Burkhardt B, Claviez A, Damm-Welk C, Drexler HG, Hummel M, Jaffe ES, Küppers R, Lefebvre C, Lisfeld J, Löffler M, Macleod RA, Nagel I, Oschlies I, Rosolowski M, Russell RB, Rymkiewicz G, Schindler D, Schlesner M, Scholtysik R, Schwaenen C, Spang R, Szczepanowski M, Trümper L, Vater I, Wessendorf S, Klapper W, Siebert R
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• An unusual mutation in the XPG gene leads to an internal in-frame deletion and a XP/CS complex phenotype, Br J Dermatol. 2014; 171(4):903-5
  Lehmann J, Schubert S, Schäfer A, Gratchev A, Apel A, Laspe P, Schiller S, Ohlenbusch A, Emmert S
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• An unusual mutation in the XPG gene leads to an internal in-frame deletion and a XP/CS complex phenotype. British Journal of Dermatology, 2014; 171: 903-905
  J. Lehmann, S. Schubert, A. Schäfer, A. Apel, P. Laspe, S. Schiller, A. Ohlenbusch, A. Gratchev, S. Emmert
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• An unusual mutation in the XPG gene leads to an internal in-frame deletion and a XP/CS complex phenotype; BJD, 2014
  J. Lehmann, S. Schubert, A. Schäfer, A. Apel, P. Laspe, S. Schiller, A. Ohlenbusch, A. Gratchev, S. Emmert
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• Characterization of genomic imbalances in diffuse large B-cell lymphoma by detailed SNP-chip analysis. Int J Cancer. 2014; 136: 1033-42
  Scholtysik R, Kreuz M, Hummel M, Rosolowski M, Szczepanowski M, Klapper W, Loeffler M, Trümper L, Siebert R, Küppers R
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• Characterization of the multifunctional XPG protein during Nucleotide-excision-repair, Dissertation Georg-August-Universität Göttingen, 2014
  Schubert, Steffen
  
• Clinical utility gene card for: Xeroderma pigmentosum. Eur J Hum Genet, 2014; 22: e1-e4
  Schubert S, Lehmann J, Kalfon L, Slor H, Falik-Zaccai TC, Emmert S
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• Entwicklung und Implementierung von Auswertungswerkzeugen für Hochdurchsatz-DNA-Kopienzahl-Analysen und deren Anwendung auf Lymphomdaten, Dissertation, 2014
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• Functional effects of the MICA-129 dimorphism on NK cell activity and association with the outcome of hematopoietic stem cell transplantation, Dissertation Georg-August-Universität Göttingen, 2014
  Isernhagen, Antje
  
• Gene-environment interaction and extension to empirical hierarchical bayes models in genome-wide association studies, Dissertation Georg-August-Universität Göttingen, 2014
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• Genomic and epigenomic co-evolution in follicular lymphomas. Leukemia. 2014 Jul 16
  Loeffler M, Kreuz M, Haake A, Hasenclever D, Trautmann H, Arnold C, Winter K, Koch K, Klapper W, Scholtysik R, Rosolowski M, Hoffmann S, Ammerpohl O, Szczepanowski M, Herrmann D, Küppers R, Pott C, Siebert R
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• Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. Blood. 2014;124(9):1460-72
  Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, Bailey NG, Schrader A, Li B, Li JZ, Ozel AB, Betz BL, Miranda RN, Medeiros LJ, Zhao L, Herling M, Lim MS, Elenitoba-Johnson KS
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• Molecular Mechanisms in Malignant Lymphomas Network Project. Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma.Haematologica. 2014 Apr;99(4):726-35
  Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, Küppers R, Lenze D, Ott G, Pott C, Richter J, Rosenwald A, Szczepanowski M, Schwaenen C, Stein H, Trautmann H, Wessendorf S, Trümper L, Loeffler M, Spang R, Kluin PM, Klapper W, Siebert R
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• Palmoplantar dermatoses: when should genes be considered? Der Hautarzt, 2014; 65: 499-512
  Seebode C., Schiller S., Emmert S., Giehl K.
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• Palmoplantar keratoderma (PPK): aquired and genetic causes of a not so rare disease. Journal of the German Society of Dermatology, 2014; 12, 781-8
  Schiller S., Seebode C., Hennies HC., Giehl K., Emmert S.
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• Plasma Applications: A Dermatological View, Contrib. Plasma Phys. 54 (2), 118-130, 2014
  R. Tiede, J. Hirschberg, G. Daeschlein, T. von Woedtke, W. Vioel, S. Emmert
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• Plasmamedizin in der Dermatologie, Haut 2014; 6, 228-233
  R. Tiede, M. Mann, W. Viol, G. Daeschlein, C. Welz, H. Wolff, T. von Woedtke, J. Lademann, S. Emmert
  
• The MAPK- activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells. Cell Cycle 2014; 13, 884-889
  Kopper, F., Binkowski, A.M., Bierwirth, C., and Dobbelstein, M.
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• The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family. AAPS journal 2014 Nov;16:1247-58
  Dos Santos Pereira, J. N., Tadjerpisheh, S., Abu Abed, M., Saadatmand, A. R., Brockmöller, J., Tzvetkov, M.
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• The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family. American Association of Pharmaceutical Scientists (AAPS) Journal. 2014; 16: 1247-1258
  dos Santos Pereira JN, Tadjerpisheh S, Abu-Abed M, Saadatmand AR, Weksler B, Romero IA, Couraud PO, Brockmöller J, Tzvetkov MV
  (See online at https://doi.org/10.1208/s12248-014-9649-9)
• Unmittelbare, dauerhafte sowie evolutionäre Anpassung an Fremdstoffexpositionen, Dissertation Universität Mainz, 2014
  Mathäs, Marianne
  
• Von seltenen genetischen Erkrankungen lernen: Hautkrebs und DNA Reparatur, Ichthyosen und epidermale Differenzierung sowie kaltes Atmosphärendruckplasma als neue Therapiemodalität. In: Spitzenforschung in der Dermatologie. Innovationen und Auszeichnungen, 2014, hrsg. von der ALPHA Informations, Lampertheim. S. 62-70
  S. Schiller, S. Schubert, J. Lehmann, C. Seebode, S. Smolorz, R. Tiede, A. Apel, P. Laspe, S. Emmert
  
• Von seltenen genetischen Erkrankungen lernen: Hautkrebs und DNA Reparatur, Ichthyosen und epidermale Differenzierung sowie kaltes Atmosphärendruckplasma als neue Therapiemodalität, Spitzenforschung in der Dermatologie, 62–70, 2014
  S. Schiller, S. Schubert, J. Lehmann, C. Seebode, S. Smolorz, R. Tiede, A. Apel, P. Laspe, S. Emmert
  
• Xeroderma pigmentosum (XP): Diagnostic procedures, interdisciplinary patient care, and novel therapeutic approach. J Dtsch Dermatol Ges. 2014; 12(10):867-72
  Lehmann J, Schubert S, Emmert S
  (See online at https://doi.org/10.1111/ddg.12419)
• “The hOCT1 SNPs Met420del and Met408Val alter imatinib uptake: Does the apparently predictive haplotype Met408-Del420 really exist?” Blood. 2014 Feb 27;123:1427-9
  Tzvetkov MV, Seitz T, Bokelmann K, Mueller T, Brockmöller J, Koepsell H
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• (2015) Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs. Pharmacol Res. 2015 Jan;91:78-87
  Marada VV, Flörl S, Kühne A, Müller J, Burckhardt G, Hagos Y
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• (2015) Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. Eur J Med Chem. 2015 Mar 6;92:723-31
  Marada VV, Flörl S, Kühne A, Burckhardt G, Hagos Y
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• (2015) Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F330-8
  Hagos Y, Hundertmark P, Shnitsar V, Marada VV, Wulf G, Burckhardt G
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• A novel mutation in the XPA gene results in two truncated protein variants and leads to a severe XP/neurological symptoms phenotype. Journal of the European Academy of Dermatology and Venereology, 2015, Volume 29, Issue 12, pages 2479–2482
  J. Lehmann, S. Schubert, A. Schäfer, P. Laspe, H. A. Haenssle, A. Ohlenbusch, A. Gratchev, S. Emmert
  (See online at https://doi.org/10.1111/jdv.12841)
• Genomic variations in the EGFR pathway in relation to skin toxicity of EGFR inhibitors analyzed by deep sequencing, Dissertation Georg-August-Universität Göttingen, 2015
  Hasheminasab, Sayed-Mohammad
  
• Global genetic analyses reveal strong inter-ethnic variability in the frequency of loss of activity of the organic cation transporter OCT1. Genome medicine 2015; 7:56
  Seitz T, Stalmann R, Dalila N, Chen J, Pojar S, Dos Santos Pereira JN, Krätzner R, Brockmöller J, Tzvetkov MV
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• High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors. Pharmacogenomics 2015, Vol 16 No 14
  Hasheminasab, SM, Tzvetkov MV, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Steffens M, Scholl C, Hichert V, Seufferlein T, Brockmöller J, Stingl JC
  (See online at https://doi.org/10.2217/pgs.15.97)
• Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und immunhistochemische Analysen, Dissertation Georg-August-Universität Göttingen, 2015
  Zimmer, Christian
  
• Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs. Pharmacogenomics 2015; 16: 115-127
  Dalila, N., Brockmöller, J., Tzvetkov, M.V., Schirmer, M., Haubrock, M., and Vormfelde, S.V.
  (See online at https://doi.org/10.2217/pgs.14.163)
• Interaction of hepatic uptake transporters with antineoplastic compounds and regulation of the expression of organic cation transporter 3 in renal carcinoma cells, Dissertation Georg-August-Universität Göttingen, 2015
  Marada, Venkata
  
• Role of 5-FU in DNA double strand break repair for improved targets in colorectal cancer therapy, Dissertation Georg-August- Universität Göttingen, 2015
  Srivnivas Sai, Upadhyayula
  
• Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells. Oncotarget. 2015;6:617-32
  Schmidt F, Kunze M, Loock AC, Dobbelstein M
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• Stress signaling pathways in the cellular response to nucleoside analogues, Dissertation Georg-August-Universität Göttingen, 2015
  Jagannathan, Veena