Characterizing intratumoral heterogeneity in glioblastoma: a radiogenomics study (B12*)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 68647618

Intratumoral heterogeneity, a hallmark feature of glioblastoma, has been suspected to be the cause of the failure of targeted therapies to date, by hosting several distinct tumor subclones with varying genomic backgrounds. We hypothesize that this heterogeneity is reflected in the imaging phenotype, and can therefore be assessed non-invasively. To this end, we will extensively characterize the genome and transcriptome of targeted biopsies in newly diagnosed glioblastoma and link this information to imaging data, ultimately mapping the genotype to the phenotype. These data may contribute to a better understanding of intratumoral dynamics and microenvironments, and ultimately the development of resistance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 824: Imaging for Selection, Monitoring and Individualisation of Cancer Therapies
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Björn Menze; Privatdozent Dr. Benedikt Wiestler