The modular function of the y-secretase in the generation of intermediate Aß species (D03)

• Subject Area: Biochemistry
• Term: from 2007 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 25065445

Processing of the amyloid precursor protein by the ß-secretase and the γ-secretase module leads to the generation of amyloid ß-peptides and a soluble intracellular C-terminal domain, which is involved in transcriptional regulation. The goal of this project is stepwise to reconstitute the enzyme/substrate complex and to structurally analyze the interaction of multiple transmembrane segments by pulsed electron–electron double resonance spectroscopy based on a GxxxG motif which was found to mediate helix-helix interactions within subunits of the γ-secretase module.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Freie Universität Berlin
• Project Head: Professor Dr. Gerhard Multhaup