Modeling of proteins under non-natural conditions: organic solvents, high pressure, high temperature (C01)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 17546514

In sub-project C.1, proteins that are widely used in industrial biotechnology are simulated under non-natural conditions to investigate the molecular mechanism of binding of solvent molecules to the protein surface, the unfolding and aggregation of proteins by organic solvents, high pressure or temperature. A more detailed understanding of the changes of protein structure and dynamics is a prerequisite for the design of improved biocatalysts and the optimization of process conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 716: Dynamic Simulation of Systems with Large Particle Numbers
• Applicant Institution: Universität Stuttgart
• Project Head: Professor Dr. Jürgen Pleiss