KFO 196:  Signal Transduction in Adaptive and Maladaptive Cardiac Remodelling

• Subject Area: Medicine ; Biology
• Term: from 2007 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 35635434

• Final Report Year: 2014

Final Report Abstract

No abstract available

Publications

• Aldosterone promotes atrial fibrillation. Eur Heart J 2011;33:2098–2108
  Reil J-C, Hohl M, Selejan S, Lipp P, Drautz F, Kazakow A, Münz BM, Müller P, Steendijk P, Reil G-H, Allessie MA, Böhm M, Neuberger H-R
  (See online at https://doi.org/10.1093/eurheartj/ehr266)
• Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea. Hypertension. 2013;62:767-774
  Linz D, Hohl M, Nickel A, Mahfoud F, Wagner M, Ewen S, Schotten U, Maack C, Wirth K, Böhm M
  (See online at https://doi.org/10.1161/HYPERTENSIONAHA.113.01728)
• HDAC4 controls histone methylation in response to elevated cardiac load. J Clin Invest 2013;123:1359-1370
  Hohl M, Wagner M, Reil JC, Müller SA, Tauchnitz M, Zimmer AM, Lehmann LH, Thiel G, Böhm M, Backs J, Maack C
  (See online at https://doi.org/10.1172/JCI61084)
• Genetically Encoded Ca2+ Indicators in Cardiac Myocytes. Circulation Research 2014;114:1623–1639
  Kaestner L, Scholz A, Tian Q, Ruppenthal S, Tabellion W, Wiesen K, Katus HA, Muller OJ, Kotlikoff MI, Lipp P
  (See online at https://doi.org/10.1161/CIRCRESAHA.114.303475)
• Improvements of left-ventricular hypertrophy and diastolic function following renal denervation – Effects beyond blood pressure and heart rate reduction. J Am Coll Cardiol. 2014;63(18):1916-1923
  Schirmer SH, Sayed MMYA, Reil JC, Ukena C, Linz D, Kindermann M, Laufs U, Mahfoud F, Böhm M
  (See online at https://doi.org/10.1016/j.jacc.2013.10.073)
• Increased beta-adrenergic inotropy in ventricular myocardium from trpm4-/- mice. Circ Res 2014;114:283-294
  Mathar I, Kecskes M, Van der Mieren G, Jacobs G, Camacho Londono JE, Uhl S, Flockerzi V, Voets T, Freichel M, Nilius B, Herijgers P, Vennekens R
  (See online at https://doi.org/10.1161/CIRCRESAHA.114.302835)
• Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet 2014;383(9917):622-629
  Krum H, Schlaich MP, Sobotka PA, Böhm M, Mahfoud F, Rocha-Singh K, Katholi R, Esler MD
  (See online at https://doi.org/10.1016/S0140-6736(13)62192-3)
• Systems genetics of liver fibrosis: identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population. PLoS One. 2014;28;9(2):e89279
  Hall RA, Liebe R, Hochrath K, Kazakov A, Alberts R, Laufs U, Böhm M, Fischer HP, Williams RW, Schughart K, Weber SN, Lammert F
  (See online at https://doi.org/10.1371/journal.pone.0089279)
• The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation. J Biol Chem 2014;289(10): 6656-6668
  Lavall D, Selzer C, Schuster P, Lenski M, Adam O, Schäfers HJ, Böhm M, Laufs U
  (See online at https://doi.org/10.1074/jbc.M113.519256)