Reversal of Hypothalamic/Midbrain Inflammation and Restoration of Central Leptin Sensitivity as a Driver of Sustained Weight Loss (A08*+)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2017 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

The increased accessibility of palatable, calorie-dense foods is a major predisposing environmentalfactors for the development of obesity. Chronic over-nutrition leads to a state of hypothalamic inflammation, central leptin and insulin resistance, subsequent hyperphagia and weight gain. Project A8 will take advantage of an established rodent bariatric surgery to study the possible differential influences of weight loss following surgery and chronic food restriction on high fat diet-induced inflammatory processes in homeostatic and hedonic feeding circuits and adipose tissue signals to the brain.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professorin Dr. Wiebke Kristin Fenske, until 6/2018; Dr. Mohamed Hankir, Ph.D., until 6/2018