Adaptive cellular mechanisms of functional reorganization and recovery after traumatic brain injury (TBI) (C02 [A07])

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 221828878

This project investigates early homeostatic, adaptive cellular mechanisms underlying neuronal dysfunction in the vicinity of a traumatic brain injury (TBI) in motor-/somatosensory cortex of mice. We characterized the different electrophysiological and morphological changes in the ipsi- and contralateral hemispheres after TBI, and identified specific alterations in ion channel properties mediating these changes. These mechanisms and their consequences for neuronal morphology and function will be analyzed in more details during the next funding period; the long-lasting effects of TBI on behavior will also be assessed, and the possibility of therapeutic intervention by correcting these mechanisms will also be determined.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Thomas Mittmann; Professorin Dr. Irmgard Tegeder