Project Details
Molecular mechanisms of direct reprogramming of fibroblasts to trophoblast stem cells
Subject Area
Reproductive Medicine, Urology
General Genetics and Functional Genome Biology
Bioinformatics and Theoretical Biology
General Genetics and Functional Genome Biology
Bioinformatics and Theoretical Biology
Term
from 2017 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 329123747
Final Report Year
2022
Final Report Abstract
No abstract available
Publications
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(2018). Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell 1–23
Schwarz, B.A., Cetinbas, M., Clement, K., Walsh, R.M., Cheloufi, S., Gu, H., Langkabel, J., Kamiya, A., Schorle, H., Meissner, A., Sadreyev, R.I., Hochedlinger, K.
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(2020). Choice of factors and medium impinge on success of ESC to TSC conversion. Placenta 90, 128–137
Kaiser, F., Kubaczka, C., Graf, M., Langer, N., Langkabel, J., Arévalo, L., Schorle, H.
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(2020). CRELD1 modulates homeostasis of the immune system in mice and humans. Nat Immunol 21, 1517-1527
Bonaguro L, Köhne M, Schmidleithner L, Schulte-Schrepping J, Warnat-Herresthal S, Horne A, Kern P, Günther P, Ter Horst R, Jaeger M, Rahmouni S, Georges M, Falk CS, Li Y, Mass E, Beyer M, Joosten LAB, Netea MG, Ulas T, Schultze JL, Aschenbrenner AC
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(2020). Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. Nat Neurosci, 23, 351-362
Werner Y, Mass E, Ashok Kumar P, Ulas T, Händler K, Horne A, Klee K, Lupp A, Schütz D, Saaber F, Redecker C, Schultze JL, Geissmann F, Stumm R
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(2020). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell 182, 1419-1440.e23
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI)
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(2021). COVID-19 and the human innate immune system. Cell 184, 1671-1692
Schultze JL & Aschenbrenner AC
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(2021). Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. Genome Med 13, 7
Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 Omics Initiative (DeCOI)
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(2021). Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Nat Commun 12, 7322
Langkabel, J., Horne, A., Bonaguro, L., Holsten, L., Hesse, T., Knaus, A., Riedel, Y., Becker, M., Händler, K., Elmzzahi, T., Bassler, K., Reusch, N., Yeghiazarian, L.H., Pecht, T., Saglam, A., Ulas, T., Aschenbrenner, A.C., Kaiser, F., Kubaczka, C., Schultze, J.L., Schorle, H.