Quantitative analysis of a spatial toggle switch and one-component signaling in bacteria (P10)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269423233

We will dissect the cell polarity switching mechanism in M. xanthus in collaboration with the Søgaard-Andersen group. Together with the Jung group, we will perform a comparative analysis of several in vivo protein-DNA target search processes involved in acid resistance, and study the interplay of three acid resistance systems in E. coli. Together with Thorben Cordes and Seán Murray, we will devise advanced methods for analyzing protein dynamics in live bacterial cells via Fluorescence Recovery After Photobleaching (FRAP) analysis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 174: Spatiotemporal dynamics of bacterial cells
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professor Dr. Ulrich Gerland