Spatiotemporal regulation of cell division and motility in Myxococcus xanthus (P01)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269423233

Spatiotemporal control mechanisms in bacteria operate to dynamically target proteins to distinct subcellular positions, thus spatially confining their activities. These mechanisms can operate in a cell cycle-dependent or -independent manner. For instance, positioning of the division site is controlled in a cell cycle-dependent manner to ensure the generation of correctly sized daughter cells with the correct chromosome complement. By contrast, motile bacteria are polarized with distinct front-rear polarity to enable efficient translocation and this polarity can change indepen-dently of the cell cycle in response to external cues. In this project, we focus on the spatiotemporal regulation of cell division and motility in Myxococcus xanthus.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 174: Spatiotemporal dynamics of bacterial cells
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professorin Dr. Lotte Sogaard-Andersen