Probing myeloid effector functions in Alzheimer's disease and immunotherapy (B09)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

We will (i) analyze functional changes of microglia harboring alterations in TREM2, known to be a risk factor Alzheimer's disease (AD), in ex vivo assays, (ii) assess whether AD pathology in A-overexpressing mice harboring myeloid cell-/microglia-specifically TREM2 alterations is changed and (iii) identify the genomic signature of such microglia. We will also dissect the molecular and operating determinants and molecules of microglia effector functions in A, immunotherapy, which - upon identification - will be validated by in vitro assay, and, ultimately in vivo with respect for their impact on modulating AD pathology.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Frank Heppner