Myeloid cells in the development of choroidal neovascularisation in the eye (B02)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Myeloid cells, including resident microglia (MG) and infiltrating macrophages (Mac) have been implicated in the development of choroidal neovascularisation (CNV) in age-related macular degeneration (AMD). Using two novel transgenic reporter mouse models for lineage tracing and fate mapping studies we will clarify the origin, dynamics and differential function of MG and Macs during ageing and CNV development. These studies will improve our understanding of the immunological processes in neovascular AMD and may lay the foundation for the development of novel improved therapeutic approaches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Ingo Hilgendorf; Professor Clemens A.K. Lange, Ph.D.