Crosstalk of myeloid cells and neural stem cells during regeneration after stroke (B01)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Inflammation orchestrates tissue remodelling and exerts a complex influence on neural stem/precursor cells (NSPCs) in the adult brain. Focusing on microglia and blood-borne macrophages, we plan to clarify the role of NSPC-inflammatory cell crosstalk with respect to its functional significance and underlying molecular signals, to identify candidates for therapeutic strategies, and assess their efficacy in stroke models. We believe that a better understanding of NSPC-myeloid crosstalk could advance the exploration of endogenous neurogenesis for the regeneration after stroke and other inflammatory conditions of the nervous system.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Dr. Francisco Fernández-Klett, until 4/2018; Professor Christian Schachtrup, Ph.D.