Funktionelle Analyse der neuronalen Anionenaustauscher mit Hilfe von transgenen Mausmodellen

• Applicants: Professor Alexander Dityatev, Ph.D.; Professor Dr. Christian Andreas Hübner
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2006 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32459114

• Final Report Year: 2012

Final Report Abstract

No abstract available

Publications

• (2006). Foxi1 directly activates the anion exchanger AE4. Biochemical J 393, 277-283
  Kurth I, Hentschke M, Hentschke S, Borgmeyer U, Gal A, Hübner CA
  
• (2007). Expression of anion exchanger AE3 influences respiratory rate in awake and isoflurane anaesthetized mice. J Physiol Pharmacol 58 Suppl 5:371-378
  Meier S, Hübner CA, Groeben H, Peters J, Bingmann D, Wiemann M
  
• (2008). Targeted gene disruption of Slc4a10 results in reduced brain ventricle size and dampens neuronal excitability. Proc Natl Acad Sci USA 105, 311-316
  Jacobs S, Ruusuvuori E, Sipilä S, Hapaanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatinkainen L, Tyynelä J, Praetorius J, Voipio J, Hübner CA
  
• (2009). Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl-/HCO3- exchange in hippocampal neurons. J Neurosci 29, 3252-3258
  Svichar N, Waheed A, Sly WS, Hennings JC, Hübner CA, and Chesler M
  
• (2009). Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice. Am J Physiol - Cell Physiol 296, C1291-C1300
  Damkier H, Prasad V, Hübner CA, Praetorius J
  
• (2009). NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development. J Neurosci. Mar 18;29(11):3419-30
  Pfeffer CK, Stein V, Keating DJ, Maier H, Rinke I, Rudhard Y, Hentschke M, Rune GM, Jentsch TJ, Hübner CA
  
• (2009). The murine AE4 promoter predominantly drives type B intercalated cell specific transcription. Histochem. Cell Biol. 132, 405-412
  Hentschke M, Hentschke S, Borgmeyer U, Hübner CA, Kurth I
  
• (2010). Identification of a novel amiloride-resistant, thiazide-sensitive NaCl reabsorption pathway in the distal nephron. J Clin Invest 120, 1627-1635
  Leviel F, Hübner CA, Morla L, Houillier P, El Moghrabi S, Brideau G, Hatim H, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, and Eladari D
  
• (2011). Synaptic glutamate release is modulated by the Na+-driven Cl-/HCO3- exchanger Slc4a8. Journal of Neuroscience, 31(20):7300-11
  Sinning A, Liebmann L, Kougioumtzes A, Westermann M, Brühl C, Hübner CA
  
• (2012). Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina. PLoS One. 2012;7(10):e46155
  Hilgen G, Huebner AK, Tanimoto N, Sothilingam V, Seide C, Garrido MG, Schmidt KF, Seeliger MW, Löwel S, Weiler R, Hübner CA, Dedek K
  (See online at https://doi.org/10.1371/journal.pone.0046155)