Mechanism of secretory cargo sorting at the trans-Golgi Network

• Applicant: Professorin Dr. Julia von Blume, Ph.D.
• Subject Area: Cell Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 323442537

• Final Report Year: 2020

Final Report Abstract

No abstract available

Publications

• Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins at the trans-Golgi Network. 2018. Dev Cell. 47 (4): 464-478
  Deng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J
  (See online at https://doi.org/10.1016/j.devcel.2018.10.012)
• Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019 May;569(7755):236-240
  Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein
  (See online at https://doi.org/10.1038/s41586-019-1167-6)
• Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep. 2019
  Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R
  (See online at https://doi.org/10.15252/embr.201846451)
• Fam20C regulates protein secretion by Cab45 phosphorylation. J Cell Biol. 2020 Jun 1;219(6):e201910089
  Hecht TK, Blank B, Steger M, Lopez V, Beck G, Ramazanov B, Mann M, Tagliabracci V, von Blume J
  (See online at https://doi.org/10.1083/jcb.201910089)
• Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. J Cell Biol. 2020 Aug 3;219(8):e201907058
  Pacheco-Fernandez N, Pakdel M, Blank B, Sanchez-Gonzalez I, Weber K, Tran ML, Hecht TK, Gautsch R, Beck G, Perez F, Hausser A, Linder S, von Blume J
  (See online at https://doi.org/10.1083/jcb.201907058)
• Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. EMBO J. 2020 Jun 22:e103457
  Pigoni M, Hsia HE, Hartmann J, Rudan Njavro J, Shmueli MD, Müller SA, Güner G, Tüshaus J, Kuhn PH, Kumar R, Gao P, Tran ML, Ramazanov B, Blank B, Hipgrave Ederveen AL, Von Blume J, Mulle C, Gunnersen JM, Wuhrer M, Rammes G, Busche MA, Koeglsperger T, Lichtenthaler SF
  (See online at https://doi.org/10.15252/embj.2019103457)