MitoBalance: Mechanismen der mitochondrialen Proteostase

• Antragstellerinnen / Antragsteller: Professor Dr. Doron Rapaport; Professorin Maya Schuldiner, Ph.D.
• Fachliche Zuordnung: Biochemie
• Förderung: Förderung von 2017 bis 2022
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 323127228

Mutations in genes encoding mitochondrial proteins underlie many human diseases with more constantly being discovered. In addition gradual decline in mitochondrial function plays a role in aging and complex disease phenotypes such as neurodegeneration and cancer. Our group brings together scientist with complementary expertise that share a passion for understanding the cross talk of mitochondria and the cellular environment. We propose to use this unifying opportunity to shine a new light on an unexplored aspect of mitochondrial biology – how the cross talk of mitochondria and the cell promotes homeostasis of the mitochondrial proteome (proteostasis) in health and disease.

• DFG-Verfahren: Deutsch-Israelische-Projektkooperationen
• Teilprojekt zu: 20. Runde der Deutsch-Israelischen Projektkooperation (2017 - 2021)
• Internationaler Bezug: Israel