Molecular regulation of endothelial barrier function (A10*)

• Subject Area: Cell Biology
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054

The barrier function of the endothelium is critically required for physiological processes in different organs of the healthy organism and, conversely, disruption of the endothelial barrier is a hallmark of many disease processes. Here, we propose to investigate how the transcription factor Yin Yang 1 (YY1), an important regulator of gene expression and chromatin organization, controls EC behavior and endothelial permeability in the central nervous system and in bone in a comparative fashion.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1009: Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Ralf H. Adams