Analysis of a SUMO switch in EGF receptor signaling (A18)

• Subject Area: Biochemistry
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278001972

SUMOylation is an essential modification that regulates hundreds of proteins including many transcription factors. The Melchior team discovered that epidermal growth factor receptor (EGFR) signaling induces rapid and transient deSUMOylation of IRF2BP transcriptional co-regulators in HeLa cells. This "SUMO switch" contributes to the transient expression of DUSP1 and potentially other immediate early genes. DUSP1 is an immediate early gene, and its product Dual specificity phos-phatase 1 is an important feedback regulator of MAP kinases. During the second funding period, the Melchior and Blüthgen team aim to expand molecular and systems insights into this "SUMO switch".

• DFG Programme: CRC/Transregios
• Subproject of: TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Nils Blüthgen; Professorin Dr. Frauke Melchior